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Endogenous Repair Signaling after Brain Injury and Complementary Bioengineering Approaches to Enhance Neural Regeneration
Traumatic brain injury (TBI) affects 5.3 million Americans annually. Despite the many long-term deficits associated with TBI, there currently are no clinically available therapies that directly address the underlying pathologies contributing to these deficits. Preclinical studies have investigated v...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429653/ https://www.ncbi.nlm.nih.gov/pubmed/25983552 http://dx.doi.org/10.4137/BMI.S20062 |
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author | Addington, Caroline P Roussas, Adam Dutta, Dipankar Stabenfeldt, Sarah E |
author_facet | Addington, Caroline P Roussas, Adam Dutta, Dipankar Stabenfeldt, Sarah E |
author_sort | Addington, Caroline P |
collection | PubMed |
description | Traumatic brain injury (TBI) affects 5.3 million Americans annually. Despite the many long-term deficits associated with TBI, there currently are no clinically available therapies that directly address the underlying pathologies contributing to these deficits. Preclinical studies have investigated various therapeutic approaches for TBI: two such approaches are stem cell transplantation and delivery of bioactive factors to mitigate the biochemical insult affiliated with TBI. However, success with either of these approaches has been limited largely due to the complexity of the injury microenvironment. As such, this review outlines the many factors of the injury microenvironment that mediate endogenous neural regeneration after TBI and the corresponding bioengineering approaches that harness these inherent signaling mechanisms to further amplify regenerative efforts. |
format | Online Article Text |
id | pubmed-4429653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-44296532015-05-15 Endogenous Repair Signaling after Brain Injury and Complementary Bioengineering Approaches to Enhance Neural Regeneration Addington, Caroline P Roussas, Adam Dutta, Dipankar Stabenfeldt, Sarah E Biomark Insights Review Traumatic brain injury (TBI) affects 5.3 million Americans annually. Despite the many long-term deficits associated with TBI, there currently are no clinically available therapies that directly address the underlying pathologies contributing to these deficits. Preclinical studies have investigated various therapeutic approaches for TBI: two such approaches are stem cell transplantation and delivery of bioactive factors to mitigate the biochemical insult affiliated with TBI. However, success with either of these approaches has been limited largely due to the complexity of the injury microenvironment. As such, this review outlines the many factors of the injury microenvironment that mediate endogenous neural regeneration after TBI and the corresponding bioengineering approaches that harness these inherent signaling mechanisms to further amplify regenerative efforts. Libertas Academica 2015-05-12 /pmc/articles/PMC4429653/ /pubmed/25983552 http://dx.doi.org/10.4137/BMI.S20062 Text en © 2015 the author(s), publisher and licensee Libertas Academica Limited This is an open-access article distributed under the terms of the Creative Commons CCCC-BY-NCNC 3.0 License. |
spellingShingle | Review Addington, Caroline P Roussas, Adam Dutta, Dipankar Stabenfeldt, Sarah E Endogenous Repair Signaling after Brain Injury and Complementary Bioengineering Approaches to Enhance Neural Regeneration |
title | Endogenous Repair Signaling after Brain Injury and Complementary Bioengineering Approaches to Enhance Neural Regeneration |
title_full | Endogenous Repair Signaling after Brain Injury and Complementary Bioengineering Approaches to Enhance Neural Regeneration |
title_fullStr | Endogenous Repair Signaling after Brain Injury and Complementary Bioengineering Approaches to Enhance Neural Regeneration |
title_full_unstemmed | Endogenous Repair Signaling after Brain Injury and Complementary Bioengineering Approaches to Enhance Neural Regeneration |
title_short | Endogenous Repair Signaling after Brain Injury and Complementary Bioengineering Approaches to Enhance Neural Regeneration |
title_sort | endogenous repair signaling after brain injury and complementary bioengineering approaches to enhance neural regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429653/ https://www.ncbi.nlm.nih.gov/pubmed/25983552 http://dx.doi.org/10.4137/BMI.S20062 |
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