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Alternative salt bridge formation in Aβ—a hallmark of early-onset Alzheimer's disease?
Recently the 3D structure of the Osaka mutant form (E22Δ) of Amyloid-β1-40 has been determined. We here compare the NMR chemical-shift with the published shifts of a brain-seeded form of wild-type Aβ and suggest that the determined mutant fold is accessible to the wild-type protein as well, with sma...
Autores principales: | Schledorn, Maarten, Meier, Beat H., Böckmann, Anja |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429654/ https://www.ncbi.nlm.nih.gov/pubmed/25988181 http://dx.doi.org/10.3389/fmolb.2015.00014 |
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