Reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington’s disease following transplantation of bone-marrow-derived mesenchymal stem cells is dependent on passage number

INTRODUCTION: Huntington’s disease (HD) is an autosomal dominant disorder caused by an expanded CAG repeat (greater than 38) on the short arm of chromosome 4, resulting in loss and dysfunction of neurons in the neostriatum and cortex, leading to cognitive decline, motor dysfunction, and death, typic...

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Detalles Bibliográficos
Autores principales: Rossignol, Julien, Fink, Kyle D, Crane, Andrew T, Davis, Kendra K, Bombard, Matthew C, Clerc, Steven, Bavar, Angela M, Lowrance, Steven A, Song, Cheng, Witte, Steven, Lescaudron, Laurent, Dunbar, Gary L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429666/
https://www.ncbi.nlm.nih.gov/pubmed/25971780
http://dx.doi.org/10.1186/scrt545

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