Cargando…

FTY720 attenuates excitotoxicity and neuroinflammation

BACKGROUND: FTY720 (fingolimod, Gilenya™), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy has been related to induced lymphopenia and consequent immunosuppression via modula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cipriani, Raffaela, Chara, Juan Carlos, Rodríguez-Antigüedad, Alfredo, Matute, Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429813/ https://www.ncbi.nlm.nih.gov/pubmed/25953296 http://dx.doi.org/10.1186/s12974-015-0308-6

Ejemplares similares

Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury
por: Cipriani, Raffaela, et al.
Publicado: (2017)

FTY720-derivatives do not induce FTY720-like lymphopenia
por: Segura-Ulate, Ismael, et al.
Publicado: (2017)

Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation
por: Wu, Celina, et al.
Publicado: (2013)

New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth
por: Alshaker, Heba, et al.
Publicado: (2017)

The antineoplastic properties of FTY720: evidence for the repurposing of fingolimod
por: Patmanathan, Sathya Narayanan, et al.
Publicado: (2015)

The emerging role of FTY720 (Fingolimod) in cancer treatment
por: White, Christopher, et al.
Publicado: (2016)

Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy
por: Enoru, Julius O., et al.
Publicado: (2016)

FTY720 Attenuates Angiotensin II-Induced Podocyte Damage via Inhibiting Inflammatory Cytokines
por: Su, Ke, et al.
Publicado: (2017)

Fingolimod (Gileyna, FTY720): Innovative treatment for multiple sclerosis
por: Pinki,, et al.
Publicado: (2011)

Antinociceptive activity of the S1P-receptor agonist FTY720
por: Coste, Ovidiu, et al.
Publicado: (2008)

FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis
por: Kremer, Laurent, et al.
Publicado: (2019)

Protective role of fingolimod (FTY720) in rats subjected to subarachnoid hemorrhage
por: Xu, Hao-Liang, et al.
Publicado: (2015)

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination
por: Blanc, Caroline A, et al.
Publicado: (2014)

FTY720, a sphingosine analog, altered placentome histoarchitecture in ewes
por: Dunlap, Kathrin A., et al.
Publicado: (2020)

Administration of FTY720 during Tourniquet-Induced Limb Ischemia Reperfusion Injury Attenuates Systemic Inflammation
por: Foster, Anthony D., et al.
Publicado: (2017)

Lymphocyte Modulation with FTY720 Improves Hemorrhagic Shock Survival in Swine
por: Hawksworth, Jason S., et al.
Publicado: (2012)

The Immunosuppressant FTY720 (Fingolimod) enhances Glycosaminoglycan depletion in articular cartilage
por: Stradner, Martin H, et al.
Publicado: (2011)

FTY-720 induces apoptosis in neuroblastoma via multiple signaling pathways
por: Lange, Ingo, et al.
Publicado: (2017)

A Pilot Microbiota Study in Parkinson’s Disease Patients versus Control Subjects, and Effects of FTY720 and FTY720-Mitoxy Therapies in Parkinsonian and Multiple System Atrophy Mouse Models
por: Vidal-Martinez, Guadalupe, et al.
Publicado: (2020)

Development and Effects of FTY720 Ophthalmic Solution on Corneal Allograft Survival
por: Liu, Zhaochuan, et al.
Publicado: (2015)

Fingolimod (FTY720): First approved oral therapy for multiple sclerosis
por: Sharma, Sushil, et al.
Publicado: (2011)

FTY720 in multiple sclerosis: the emerging evidence of its therapeutic value
por: Thomson, Andrew
Publicado: (2006)

FTY720 restores endothelial cell permeability induced by malaria sera
por: Oggungwan, Karanyaporn, et al.
Publicado: (2018)

Effect of FTY720P on lipid accumulation in HEPG2 cells
por: Rida, Reem, et al.
Publicado: (2023)

FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans
por: Yu, Hong, et al.
Publicado: (2015)

FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model
por: Szymiczek, Agata, et al.
Publicado: (2017)

Fingolimod (FTY720) Stimulates Ca(2+)/Calcineurin Signaling in Fission Yeast
por: Hagihara, Kanako, et al.
Publicado: (2013)

Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats
por: Wang, Liangrong, et al.
Publicado: (2017)

Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and Autophagy
por: Sun, Rui-zhen, et al.
Publicado: (2018)

The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars
por: Aoki, Masayo, et al.
Publicado: (2020)

FTY720 attenuates APAP-induced liver injury via the JAK2/STAT3 signaling pathway
por: He, Xiangmin, et al.
Publicado: (2022)

The effect of the sphingosine‐1‐phosphate analogue FTY720 on atrioventricular nodal tissue
por: Egom, Emmanuel E., et al.
Publicado: (2015)

FTY720 (Fingolimod) sensitizes hepatocellular carcinoma cells to sorafenib-mediated cytotoxicity
por: Ahmed, Dilruba, et al.
Publicado: (2015)

FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts
por: Garner, Evan F., et al.
Publicado: (2018)

Coordinate Involvement of Cell Cycle Arrest and Apoptosis Strengthen the Effect of FTY720
por: Nagahara, Yukitoshi, et al.
Publicado: (2001)

Topical application of FTY720 and cyclosporin A prolong corneal graft survival in mice
por: Liu, Yong, et al.
Publicado: (2012)

FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons
por: Takasugi, Nobumasa, et al.
Publicado: (2013)

FTY720 attenuates accumulation of EMAP-II(+) and MHC-II(+) monocytes in early lesions of rat traumatic brain injury
por: Zhang, Zhiyuan, et al.
Publicado: (2007)

Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) Attenuates Myocardial Fibrosis in Post-heterotopic Heart Transplantation
por: Ahmed, Naseer, et al.
Publicado: (2017)

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
por: Tonelli, Francesca, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_kgk36p1o8l2o573dkq5tomprr8