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Metastasis of nasopharyngeal carcinoma to parotid lymph nodes: a retrospective study

BACKGROUND: Malignant parotid tumors are rare metastases originating from nasopharyngeal carcinoma (NPC). This study aimed to investigate the clinicopathological features and outcome of patients with metastasis of NPC to parotid lymph nodes after surgical therapy. METHODS: We enrolled 14 NPC patient...

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Autores principales: Wang, Shengye, Lou, Jianlin, Zhang, Suzhan, Guo, Liang, Wang, Kejing, Ge, Minghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429829/
https://www.ncbi.nlm.nih.gov/pubmed/25622525
http://dx.doi.org/10.1186/1477-7819-13-1
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author Wang, Shengye
Lou, Jianlin
Zhang, Suzhan
Guo, Liang
Wang, Kejing
Ge, Minghua
author_facet Wang, Shengye
Lou, Jianlin
Zhang, Suzhan
Guo, Liang
Wang, Kejing
Ge, Minghua
author_sort Wang, Shengye
collection PubMed
description BACKGROUND: Malignant parotid tumors are rare metastases originating from nasopharyngeal carcinoma (NPC). This study aimed to investigate the clinicopathological features and outcome of patients with metastasis of NPC to parotid lymph nodes after surgical therapy. METHODS: We enrolled 14 NPC patients who had metastatic disease to parotid lymph nodes after IMRT. They received surgical treatment by total parotidectomy with neck dissection, superficial parotidectomy with neck dissection, partial parotidectomy with neck dissection, total parotidectomy, or superficial parotidectomy. Their age, gender, histopathology, clinical findings, and treatment outcome were analyzed. RESULTS: After radiotherapy, parotid metastasis represented as uncontrolled disease in three cases and as recurrent disease in 11 cases. All the 14 patients received salvaged surgery successfully. Pathologic findings showed grade 3 in most patients. The follow-up ranged from 11 to 120 months and the overall three- and five-year survival was 49.5% and 37.1%, respectively. CONCLUSIONS: Metastasis to parotid lymph nodes should be examined in NPC patients after IMRT. Resection of the inferior parotid lymph nodes is recommended for patients with cervical metastasis, and superficial or total parotidectomy and adjuvant therapy are recommended for intraparotid lymph node metastasis.
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spelling pubmed-44298292015-05-14 Metastasis of nasopharyngeal carcinoma to parotid lymph nodes: a retrospective study Wang, Shengye Lou, Jianlin Zhang, Suzhan Guo, Liang Wang, Kejing Ge, Minghua World J Surg Oncol Research BACKGROUND: Malignant parotid tumors are rare metastases originating from nasopharyngeal carcinoma (NPC). This study aimed to investigate the clinicopathological features and outcome of patients with metastasis of NPC to parotid lymph nodes after surgical therapy. METHODS: We enrolled 14 NPC patients who had metastatic disease to parotid lymph nodes after IMRT. They received surgical treatment by total parotidectomy with neck dissection, superficial parotidectomy with neck dissection, partial parotidectomy with neck dissection, total parotidectomy, or superficial parotidectomy. Their age, gender, histopathology, clinical findings, and treatment outcome were analyzed. RESULTS: After radiotherapy, parotid metastasis represented as uncontrolled disease in three cases and as recurrent disease in 11 cases. All the 14 patients received salvaged surgery successfully. Pathologic findings showed grade 3 in most patients. The follow-up ranged from 11 to 120 months and the overall three- and five-year survival was 49.5% and 37.1%, respectively. CONCLUSIONS: Metastasis to parotid lymph nodes should be examined in NPC patients after IMRT. Resection of the inferior parotid lymph nodes is recommended for patients with cervical metastasis, and superficial or total parotidectomy and adjuvant therapy are recommended for intraparotid lymph node metastasis. BioMed Central 2015-01-26 /pmc/articles/PMC4429829/ /pubmed/25622525 http://dx.doi.org/10.1186/1477-7819-13-1 Text en © Wang et al.; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Wang, Shengye
Lou, Jianlin
Zhang, Suzhan
Guo, Liang
Wang, Kejing
Ge, Minghua
Metastasis of nasopharyngeal carcinoma to parotid lymph nodes: a retrospective study
title Metastasis of nasopharyngeal carcinoma to parotid lymph nodes: a retrospective study
title_full Metastasis of nasopharyngeal carcinoma to parotid lymph nodes: a retrospective study
title_fullStr Metastasis of nasopharyngeal carcinoma to parotid lymph nodes: a retrospective study
title_full_unstemmed Metastasis of nasopharyngeal carcinoma to parotid lymph nodes: a retrospective study
title_short Metastasis of nasopharyngeal carcinoma to parotid lymph nodes: a retrospective study
title_sort metastasis of nasopharyngeal carcinoma to parotid lymph nodes: a retrospective study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429829/
https://www.ncbi.nlm.nih.gov/pubmed/25622525
http://dx.doi.org/10.1186/1477-7819-13-1
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