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Outcomes in the offspring of mothers with pre-diabetes during pregnancy: a protocol for a systematic review

BACKGROUND: Despite the increasing prevalence of pre-diabetes worldwide, there is insufficient literature on the impact of gestational pre-diabetes on offspring outcomes. The objective of this systematic review is to determine the risk of developing adverse outcomes for the offspring in women with p...

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Autores principales: Swaleh, Rukia, Zeng, Ling, Mbuagbaw, Lawrence, Morrison, Katherine M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429909/
https://www.ncbi.nlm.nih.gov/pubmed/25957870
http://dx.doi.org/10.1186/s13643-015-0051-1
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author Swaleh, Rukia
Zeng, Ling
Mbuagbaw, Lawrence
Morrison, Katherine M
author_facet Swaleh, Rukia
Zeng, Ling
Mbuagbaw, Lawrence
Morrison, Katherine M
author_sort Swaleh, Rukia
collection PubMed
description BACKGROUND: Despite the increasing prevalence of pre-diabetes worldwide, there is insufficient literature on the impact of gestational pre-diabetes on offspring outcomes. The objective of this systematic review is to determine the risk of developing adverse outcomes for the offspring in women with pre-diabetes compared to women with normal glucose levels and women with gestational diabetes mellitus. METHODS/DESIGN: A systematic search of the published literature will be conducted for experimental and observational studies that report outcomes in the offspring of mothers with pre-diabetes during pregnancy. Databases including EMBASE, PsycINFO, and PubMed will be searched from 1979 (the year when the terms impaired glucose tolerance and pre-diabetes were coined) to December 2014. Screening of identified articles and data extraction will be conducted in duplicate and independently. Methodological quality of the included studies will be assessed using the Newcastle-Ottawa scale. Discrepancies will be resolved by consensus or by consulting a third author. Meta-analyses will be performed, and findings will be reported according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) and the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. DISCUSSION: Determining the effect of pre-diabetes on offspring outcome will be important for clinicians providing care to pregnant women and their offspring. This review will also identify any gaps in the current literature on this topic and provide direction for future research in this area of study. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015015536
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spelling pubmed-44299092015-05-14 Outcomes in the offspring of mothers with pre-diabetes during pregnancy: a protocol for a systematic review Swaleh, Rukia Zeng, Ling Mbuagbaw, Lawrence Morrison, Katherine M Syst Rev Protocol BACKGROUND: Despite the increasing prevalence of pre-diabetes worldwide, there is insufficient literature on the impact of gestational pre-diabetes on offspring outcomes. The objective of this systematic review is to determine the risk of developing adverse outcomes for the offspring in women with pre-diabetes compared to women with normal glucose levels and women with gestational diabetes mellitus. METHODS/DESIGN: A systematic search of the published literature will be conducted for experimental and observational studies that report outcomes in the offspring of mothers with pre-diabetes during pregnancy. Databases including EMBASE, PsycINFO, and PubMed will be searched from 1979 (the year when the terms impaired glucose tolerance and pre-diabetes were coined) to December 2014. Screening of identified articles and data extraction will be conducted in duplicate and independently. Methodological quality of the included studies will be assessed using the Newcastle-Ottawa scale. Discrepancies will be resolved by consensus or by consulting a third author. Meta-analyses will be performed, and findings will be reported according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) and the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. DISCUSSION: Determining the effect of pre-diabetes on offspring outcome will be important for clinicians providing care to pregnant women and their offspring. This review will also identify any gaps in the current literature on this topic and provide direction for future research in this area of study. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015015536 BioMed Central 2015-05-10 /pmc/articles/PMC4429909/ /pubmed/25957870 http://dx.doi.org/10.1186/s13643-015-0051-1 Text en © Swaleh et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Protocol
Swaleh, Rukia
Zeng, Ling
Mbuagbaw, Lawrence
Morrison, Katherine M
Outcomes in the offspring of mothers with pre-diabetes during pregnancy: a protocol for a systematic review
title Outcomes in the offspring of mothers with pre-diabetes during pregnancy: a protocol for a systematic review
title_full Outcomes in the offspring of mothers with pre-diabetes during pregnancy: a protocol for a systematic review
title_fullStr Outcomes in the offspring of mothers with pre-diabetes during pregnancy: a protocol for a systematic review
title_full_unstemmed Outcomes in the offspring of mothers with pre-diabetes during pregnancy: a protocol for a systematic review
title_short Outcomes in the offspring of mothers with pre-diabetes during pregnancy: a protocol for a systematic review
title_sort outcomes in the offspring of mothers with pre-diabetes during pregnancy: a protocol for a systematic review
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429909/
https://www.ncbi.nlm.nih.gov/pubmed/25957870
http://dx.doi.org/10.1186/s13643-015-0051-1
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