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MS in South Asians in England: early disease onset and novel pattern of myelin autoimmunity
BACKGROUND: Epidemiological studies describe a latitude gradient for increased MS prevalence and a preponderance of disease in Caucasian individuals. However, individuals from other ethnic backgrounds and low-risk regions can acquire a raised risk through migration. Nearly a fifth of the London popu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429974/ https://www.ncbi.nlm.nih.gov/pubmed/25935418 http://dx.doi.org/10.1186/s12883-015-0324-2 |
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author | Nicholas, Richard S Kostadima, Vassiliki Hanspal, Maya Wakerley, Benjamin R Sergeant, Ruhena Decuypere, Saskia Malik, Omar Boyton, Rosemary J Altmann, Daniel M |
author_facet | Nicholas, Richard S Kostadima, Vassiliki Hanspal, Maya Wakerley, Benjamin R Sergeant, Ruhena Decuypere, Saskia Malik, Omar Boyton, Rosemary J Altmann, Daniel M |
author_sort | Nicholas, Richard S |
collection | PubMed |
description | BACKGROUND: Epidemiological studies describe a latitude gradient for increased MS prevalence and a preponderance of disease in Caucasian individuals. However, individuals from other ethnic backgrounds and low-risk regions can acquire a raised risk through migration. Nearly a fifth of the London population is of Asian/Asian-British origin and a significant proportion of referrals are from this group. METHODS: We investigated whether there were differences in timing, presentation, severity, and immunology of disease (with respect to CD4 myelin epitope recognition) between individuals in London with MS who were either of S. Asian or Caucasian origin. Individuals of S. Asian origin with MS were compared with healthy S. Asian controls, individuals with MS and of Caucasian origin and Caucasian controls. RESULTS: Age at MS onset is significantly lower in the S. Asian group, attributable to earlier onset specifically in UK-born individuals, though clinical presentation is similar. Analysis of CD4 autoimmunity to myelin antigens shows disease in S. Asian individuals to encompass recognition of novel epitopes; immunity to MBP116-130 in S. Asian individuals was highly disease-specific. CONCLUSIONS: These findings emphasize the need to define disease profiles across ethnicities and identify environmental triggers conferring acquired risk. Such findings must inform choices for immunotherapeutic interventions suitable for all, across ethnicities. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12883-015-0324-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4429974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44299742015-05-14 MS in South Asians in England: early disease onset and novel pattern of myelin autoimmunity Nicholas, Richard S Kostadima, Vassiliki Hanspal, Maya Wakerley, Benjamin R Sergeant, Ruhena Decuypere, Saskia Malik, Omar Boyton, Rosemary J Altmann, Daniel M BMC Neurol Research Article BACKGROUND: Epidemiological studies describe a latitude gradient for increased MS prevalence and a preponderance of disease in Caucasian individuals. However, individuals from other ethnic backgrounds and low-risk regions can acquire a raised risk through migration. Nearly a fifth of the London population is of Asian/Asian-British origin and a significant proportion of referrals are from this group. METHODS: We investigated whether there were differences in timing, presentation, severity, and immunology of disease (with respect to CD4 myelin epitope recognition) between individuals in London with MS who were either of S. Asian or Caucasian origin. Individuals of S. Asian origin with MS were compared with healthy S. Asian controls, individuals with MS and of Caucasian origin and Caucasian controls. RESULTS: Age at MS onset is significantly lower in the S. Asian group, attributable to earlier onset specifically in UK-born individuals, though clinical presentation is similar. Analysis of CD4 autoimmunity to myelin antigens shows disease in S. Asian individuals to encompass recognition of novel epitopes; immunity to MBP116-130 in S. Asian individuals was highly disease-specific. CONCLUSIONS: These findings emphasize the need to define disease profiles across ethnicities and identify environmental triggers conferring acquired risk. Such findings must inform choices for immunotherapeutic interventions suitable for all, across ethnicities. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12883-015-0324-2) contains supplementary material, which is available to authorized users. BioMed Central 2015-05-03 /pmc/articles/PMC4429974/ /pubmed/25935418 http://dx.doi.org/10.1186/s12883-015-0324-2 Text en © Nicholas et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Nicholas, Richard S Kostadima, Vassiliki Hanspal, Maya Wakerley, Benjamin R Sergeant, Ruhena Decuypere, Saskia Malik, Omar Boyton, Rosemary J Altmann, Daniel M MS in South Asians in England: early disease onset and novel pattern of myelin autoimmunity |
title | MS in South Asians in England: early disease onset and novel pattern of myelin autoimmunity |
title_full | MS in South Asians in England: early disease onset and novel pattern of myelin autoimmunity |
title_fullStr | MS in South Asians in England: early disease onset and novel pattern of myelin autoimmunity |
title_full_unstemmed | MS in South Asians in England: early disease onset and novel pattern of myelin autoimmunity |
title_short | MS in South Asians in England: early disease onset and novel pattern of myelin autoimmunity |
title_sort | ms in south asians in england: early disease onset and novel pattern of myelin autoimmunity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429974/ https://www.ncbi.nlm.nih.gov/pubmed/25935418 http://dx.doi.org/10.1186/s12883-015-0324-2 |
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