Mobile genetic elements in Clostridium difficile and their role in genome function

Approximately 11% the Clostridium difficile genome is made up of mobile genetic elements which have a profound effect on the biology of the organism. This includes transfer of antibiotic resistance and other factors that allow the organism to survive challenging environments, modulation of toxin gen...

Descripción completa

Detalles Bibliográficos
Autores principales: Mullany, Peter, Allan, Elaine, Roberts, Adam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430133/
https://www.ncbi.nlm.nih.gov/pubmed/25576774
http://dx.doi.org/10.1016/j.resmic.2014.12.005
_version_ 1782371131582316544
author Mullany, Peter
Allan, Elaine
Roberts, Adam P.
author_facet Mullany, Peter
Allan, Elaine
Roberts, Adam P.
author_sort Mullany, Peter
collection PubMed
description Approximately 11% the Clostridium difficile genome is made up of mobile genetic elements which have a profound effect on the biology of the organism. This includes transfer of antibiotic resistance and other factors that allow the organism to survive challenging environments, modulation of toxin gene expression, transfer of the toxin genes themselves and the conversion of non-toxigenic strains to toxin producers. Mobile genetic elements have also been adapted by investigators to probe the biology of the organism and the various ways in which these have been used are reviewed.
format Online
Article
Text
id pubmed-4430133
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-44301332015-05-15 Mobile genetic elements in Clostridium difficile and their role in genome function Mullany, Peter Allan, Elaine Roberts, Adam P. Res Microbiol Article Approximately 11% the Clostridium difficile genome is made up of mobile genetic elements which have a profound effect on the biology of the organism. This includes transfer of antibiotic resistance and other factors that allow the organism to survive challenging environments, modulation of toxin gene expression, transfer of the toxin genes themselves and the conversion of non-toxigenic strains to toxin producers. Mobile genetic elements have also been adapted by investigators to probe the biology of the organism and the various ways in which these have been used are reviewed. Elsevier 2015-05 /pmc/articles/PMC4430133/ /pubmed/25576774 http://dx.doi.org/10.1016/j.resmic.2014.12.005 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mullany, Peter
Allan, Elaine
Roberts, Adam P.
Mobile genetic elements in Clostridium difficile and their role in genome function
title Mobile genetic elements in Clostridium difficile and their role in genome function
title_full Mobile genetic elements in Clostridium difficile and their role in genome function
title_fullStr Mobile genetic elements in Clostridium difficile and their role in genome function
title_full_unstemmed Mobile genetic elements in Clostridium difficile and their role in genome function
title_short Mobile genetic elements in Clostridium difficile and their role in genome function
title_sort mobile genetic elements in clostridium difficile and their role in genome function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430133/
https://www.ncbi.nlm.nih.gov/pubmed/25576774
http://dx.doi.org/10.1016/j.resmic.2014.12.005
work_keys_str_mv AT mullanypeter mobilegeneticelementsinclostridiumdifficileandtheirroleingenomefunction
AT allanelaine mobilegeneticelementsinclostridiumdifficileandtheirroleingenomefunction
AT robertsadamp mobilegeneticelementsinclostridiumdifficileandtheirroleingenomefunction

Ejemplares similares