Genomes, neurotoxins and biology of Clostridium botulinum Group I and Group II

Recent developments in whole genome sequencing have made a substantial contribution to understanding the genomes, neurotoxins and biology of Clostridium botulinum Group I (proteolytic C. botulinum) and C. botulinum Group II (non-proteolytic C. botulinum). Two different approaches are used to study g...

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Autores principales: Carter, Andrew T., Peck, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430135/
https://www.ncbi.nlm.nih.gov/pubmed/25445012
http://dx.doi.org/10.1016/j.resmic.2014.10.010
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author Carter, Andrew T.
Peck, Michael W.
author_facet Carter, Andrew T.
Peck, Michael W.
author_sort Carter, Andrew T.
collection PubMed
description Recent developments in whole genome sequencing have made a substantial contribution to understanding the genomes, neurotoxins and biology of Clostridium botulinum Group I (proteolytic C. botulinum) and C. botulinum Group II (non-proteolytic C. botulinum). Two different approaches are used to study genomics in these bacteria; comparative whole genome microarrays and direct comparison of complete genome DNA sequences. The properties of the different types of neurotoxin formed, and different neurotoxin gene clusters found in C. botulinum Groups I and II are explored. Specific examples of botulinum neurotoxin genes are chosen for an in-depth discussion of neurotoxin gene evolution. The most recent cases of foodborne botulism are summarised.
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spelling pubmed-44301352015-05-15 Genomes, neurotoxins and biology of Clostridium botulinum Group I and Group II Carter, Andrew T. Peck, Michael W. Res Microbiol Article Recent developments in whole genome sequencing have made a substantial contribution to understanding the genomes, neurotoxins and biology of Clostridium botulinum Group I (proteolytic C. botulinum) and C. botulinum Group II (non-proteolytic C. botulinum). Two different approaches are used to study genomics in these bacteria; comparative whole genome microarrays and direct comparison of complete genome DNA sequences. The properties of the different types of neurotoxin formed, and different neurotoxin gene clusters found in C. botulinum Groups I and II are explored. Specific examples of botulinum neurotoxin genes are chosen for an in-depth discussion of neurotoxin gene evolution. The most recent cases of foodborne botulism are summarised. Elsevier 2015-05 /pmc/articles/PMC4430135/ /pubmed/25445012 http://dx.doi.org/10.1016/j.resmic.2014.10.010 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Carter, Andrew T.
Peck, Michael W.
Genomes, neurotoxins and biology of Clostridium botulinum Group I and Group II
title Genomes, neurotoxins and biology of Clostridium botulinum Group I and Group II
title_full Genomes, neurotoxins and biology of Clostridium botulinum Group I and Group II
title_fullStr Genomes, neurotoxins and biology of Clostridium botulinum Group I and Group II
title_full_unstemmed Genomes, neurotoxins and biology of Clostridium botulinum Group I and Group II
title_short Genomes, neurotoxins and biology of Clostridium botulinum Group I and Group II
title_sort genomes, neurotoxins and biology of clostridium botulinum group i and group ii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430135/
https://www.ncbi.nlm.nih.gov/pubmed/25445012
http://dx.doi.org/10.1016/j.resmic.2014.10.010
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