Clearance of persistent hepatitis C virus infection using a claudin-1-targeting monoclonal antibody

Hepatitis C virus (HCV) infection is a leading cause of liver cirrhosis and cancer(1). Cell entry of HCV(2) and other pathogens(3-5) is mediated by tight junction (TJ) proteins, but successful therapeutic targeting of TJ proteins has not been reported yet. Using a human liver-chimeric mouse model(6)...

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Detalles Bibliográficos
Autores principales: Mailly, Laurent, Xiao, Fei, Lupberger, Joachim, Wilson, Garrick K., Aubert, Philippe, Duong, François H. T., Calabrese, Diego, Leboeuf, Céline, Fofana, Isabel, Thumann, Christine, Bandiera, Simonetta, Lütgehetmann, Marc, Volz, Tassilo, Davis, Christopher, Harris, Helen J., Mee, Christopher J., Girardi, Erika, Chane-Woon-Ming, Béatrice, Ericsson, Maria, Fletcher, Nicola, Bartenschlager, Ralf, Pessaux, Patrick, Vercauteren, Koen, Meuleman, Philip, Villa, Pascal, Kaderali, Lars, Pfeffer, Sébastien, Heim, Markus H., Neunlist, Michel, Zeisel, Mirjam B., Dandri, Maura, McKeating, Jane A., Robinet, Eric, Baumert, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430301/
https://www.ncbi.nlm.nih.gov/pubmed/25798937
http://dx.doi.org/10.1038/nbt.3179

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