Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing

Undetected and untreated, low-levels of drug resistant (DR) subpopulations in clinical Mycobacterium tuberculosis (Mtb) infections may lead to development of DR-tuberculosis, potentially resulting in treatment failure. Current phenotypic DR susceptibility testing has a theoretical potential for 1% s...

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Detalles Bibliográficos
Autores principales: Colman, Rebecca E., Schupp, James M., Hicks, Nathan D., Smith, David E., Buchhagen, Jordan L., Valafar, Faramarz, Crudu, Valeriu, Romancenco, Elena, Noroc, Ecaterina, Jackson, Lynn, Catanzaro, Donald G., Rodwell, Timothy C., Catanzaro, Antonino, Keim, Paul, Engelthaler, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430321/
https://www.ncbi.nlm.nih.gov/pubmed/25970423
http://dx.doi.org/10.1371/journal.pone.0126626

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