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Epigenome editing by a CRISPR/Cas9-based acetyltransferase activates genes from promoters and enhancers

Technologies that facilitate the targeted manipulation of epigenetic marks could be used to precisely control cell phenotype or interrogate the relationship between the epigenome and transcriptional control. Here we have generated a programmable acetyltransferase based on the CRISPR/Cas9 gene regula...

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Detalles Bibliográficos
Autores principales:	Hilton, Isaac B., D’Ippolito, Anthony M., Vockley, Christopher M., Thakore, Pratiksha I., Crawford, Gregory E., Reddy, Timothy E., Gersbach, Charles A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430400/ https://www.ncbi.nlm.nih.gov/pubmed/25849900 http://dx.doi.org/10.1038/nbt.3199

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