Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of I(Ks) and Ca(2+) Cycling

BACKGROUND: Remodeling of cardiac repolarizing currents, such as the downregulation of slowly activating K(+) channels (I(Ks)), could underlie ventricular fibrillation (VF) in heart failure (HF). We evaluated the role of I (ks) remodeling in VF susceptibility using a tachypacing HF model of transgen...

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Detalles Bibliográficos
Autores principales: Lau, Emily, Kossidas, Konstantinos, Kim, Tae Yun, Kunitomo, Yukiko, Ziv, Ohad, Zhen, Song, Taylor, Chantel, Schofield, Lorraine, Yammine, Joe, Liu, Gongxin, Peng, Xuwen, Qu, Zhilin, Koren, Gideon, Choi, Bum-Rak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430457/
https://www.ncbi.nlm.nih.gov/pubmed/25970695
http://dx.doi.org/10.1371/journal.pone.0122754

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