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Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications

Vascular complications are major causes of morbidity and mortality in type 2 diabetes patients. Mitochondrial reactive oxygen species (ROS) generation and a lack of efficient antioxidant machinery, a result of hyperglycaemia, mainly contribute to this problem. Although advances in therapy have signi...

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Detalles Bibliográficos
Autores principales: Togliatto, Gabriele, Dentelli, Patrizia, Brizzi, Maria Felice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430641/
https://www.ncbi.nlm.nih.gov/pubmed/26064979
http://dx.doi.org/10.1155/2015/373708
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author Togliatto, Gabriele
Dentelli, Patrizia
Brizzi, Maria Felice
author_facet Togliatto, Gabriele
Dentelli, Patrizia
Brizzi, Maria Felice
author_sort Togliatto, Gabriele
collection PubMed
description Vascular complications are major causes of morbidity and mortality in type 2 diabetes patients. Mitochondrial reactive oxygen species (ROS) generation and a lack of efficient antioxidant machinery, a result of hyperglycaemia, mainly contribute to this problem. Although advances in therapy have significantly reduced both morbidity and mortality in diabetic individuals, diabetes-associated vascular complications are still one of the most challenging health problems worldwide. New healing options are urgently needed as current therapeutics are failing to improve long-term outcomes. Particular effort has recently been devoted to understanding the functional relationship between chromatin structure regulation and the persistent change in gene expression which is driven by hyperglycaemia and which accounts for long-lasting diabetic complications. A detailed investigation into epigenetic chromatin modifications in type 2 diabetes is underway. This will be particularly useful in the design of mechanism-based therapeutics which interfere with long-lasting activating epigenetics and improve patient outcomes. We herein provide an overview of the most relevant mechanisms that account for hyperglycaemia-induced changes in chromatin structure; the most relevant mechanism is called “metabolic memory.”
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spelling pubmed-44306412015-06-10 Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications Togliatto, Gabriele Dentelli, Patrizia Brizzi, Maria Felice J Diabetes Res Review Article Vascular complications are major causes of morbidity and mortality in type 2 diabetes patients. Mitochondrial reactive oxygen species (ROS) generation and a lack of efficient antioxidant machinery, a result of hyperglycaemia, mainly contribute to this problem. Although advances in therapy have significantly reduced both morbidity and mortality in diabetic individuals, diabetes-associated vascular complications are still one of the most challenging health problems worldwide. New healing options are urgently needed as current therapeutics are failing to improve long-term outcomes. Particular effort has recently been devoted to understanding the functional relationship between chromatin structure regulation and the persistent change in gene expression which is driven by hyperglycaemia and which accounts for long-lasting diabetic complications. A detailed investigation into epigenetic chromatin modifications in type 2 diabetes is underway. This will be particularly useful in the design of mechanism-based therapeutics which interfere with long-lasting activating epigenetics and improve patient outcomes. We herein provide an overview of the most relevant mechanisms that account for hyperglycaemia-induced changes in chromatin structure; the most relevant mechanism is called “metabolic memory.” Hindawi Publishing Corporation 2015 2015-04-30 /pmc/articles/PMC4430641/ /pubmed/26064979 http://dx.doi.org/10.1155/2015/373708 Text en Copyright © 2015 Gabriele Togliatto et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Togliatto, Gabriele
Dentelli, Patrizia
Brizzi, Maria Felice
Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications
title Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications
title_full Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications
title_fullStr Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications
title_full_unstemmed Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications
title_short Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications
title_sort skewed epigenetics: an alternative therapeutic option for diabetes complications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430641/
https://www.ncbi.nlm.nih.gov/pubmed/26064979
http://dx.doi.org/10.1155/2015/373708
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