Dolutegravir-based antiretroviral therapy in a severely overweight child with a multidrug-resistant human immunodeficiency virus infection. A case report and review

The management of multidrug-resistant human immunodeficiency virus (MDR HIV) infections in children is particularly challenging due to the lack of experience with new drugs. Dolutegravir, combined with an optimized antiretroviral background therapy, is promising for the treatment of MDR HIV and has...

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Autores principales: Wagner, N., Wyler-Lazarevic, C.A., Yerly, S., Samer, C., Peytavin, G., Posfay-Barbe, K.M., Calmy, A., Ambrosioni, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430707/
https://www.ncbi.nlm.nih.gov/pubmed/26082840
http://dx.doi.org/10.1016/j.nmni.2015.02.003
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author Wagner, N.
Wyler-Lazarevic, C.A.
Yerly, S.
Samer, C.
Peytavin, G.
Posfay-Barbe, K.M.
Calmy, A.
Ambrosioni, J.
author_facet Wagner, N.
Wyler-Lazarevic, C.A.
Yerly, S.
Samer, C.
Peytavin, G.
Posfay-Barbe, K.M.
Calmy, A.
Ambrosioni, J.
author_sort Wagner, N.
collection PubMed
description The management of multidrug-resistant human immunodeficiency virus (MDR HIV) infections in children is particularly challenging due to the lack of experience with new drugs. Dolutegravir, combined with an optimized antiretroviral background therapy, is promising for the treatment of MDR HIV and has been approved recently for adults and adolescents. Data for children are extremely limited. We describe the efficacy, safety and plasmatic levels of a dolutegravir-based, complex active antiretroviral treatment regimen in a severely overweight 11-year-old child infected with an MDR HIV strain.
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spelling pubmed-44307072015-08-24 Dolutegravir-based antiretroviral therapy in a severely overweight child with a multidrug-resistant human immunodeficiency virus infection. A case report and review Wagner, N. Wyler-Lazarevic, C.A. Yerly, S. Samer, C. Peytavin, G. Posfay-Barbe, K.M. Calmy, A. Ambrosioni, J. New Microbes New Infect Mini-Review The management of multidrug-resistant human immunodeficiency virus (MDR HIV) infections in children is particularly challenging due to the lack of experience with new drugs. Dolutegravir, combined with an optimized antiretroviral background therapy, is promising for the treatment of MDR HIV and has been approved recently for adults and adolescents. Data for children are extremely limited. We describe the efficacy, safety and plasmatic levels of a dolutegravir-based, complex active antiretroviral treatment regimen in a severely overweight 11-year-old child infected with an MDR HIV strain. Elsevier 2015-02-27 /pmc/articles/PMC4430707/ /pubmed/26082840 http://dx.doi.org/10.1016/j.nmni.2015.02.003 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mini-Review
Wagner, N.
Wyler-Lazarevic, C.A.
Yerly, S.
Samer, C.
Peytavin, G.
Posfay-Barbe, K.M.
Calmy, A.
Ambrosioni, J.
Dolutegravir-based antiretroviral therapy in a severely overweight child with a multidrug-resistant human immunodeficiency virus infection. A case report and review
title Dolutegravir-based antiretroviral therapy in a severely overweight child with a multidrug-resistant human immunodeficiency virus infection. A case report and review
title_full Dolutegravir-based antiretroviral therapy in a severely overweight child with a multidrug-resistant human immunodeficiency virus infection. A case report and review
title_fullStr Dolutegravir-based antiretroviral therapy in a severely overweight child with a multidrug-resistant human immunodeficiency virus infection. A case report and review
title_full_unstemmed Dolutegravir-based antiretroviral therapy in a severely overweight child with a multidrug-resistant human immunodeficiency virus infection. A case report and review
title_short Dolutegravir-based antiretroviral therapy in a severely overweight child with a multidrug-resistant human immunodeficiency virus infection. A case report and review
title_sort dolutegravir-based antiretroviral therapy in a severely overweight child with a multidrug-resistant human immunodeficiency virus infection. a case report and review
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430707/
https://www.ncbi.nlm.nih.gov/pubmed/26082840
http://dx.doi.org/10.1016/j.nmni.2015.02.003
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