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Transcriptional changes associated with resistance to inhibitors of epidermal growth factor receptor revealed using metaanalysis

BACKGROUND: EGFR is important in maintaining metabolic homeostasis in healthy cells, but in tumors it activates downstream signaling pathways, causing proliferation, angiogenesis, invasion and metastasis. Consequently, EGFR is targeted in cancers using reversible, irreversible or antibody inhibitors...

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Detalles Bibliográficos
Autores principales:	Younis, Sidra, Javed, Qamar, Blumenberg, Miroslav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430867/ https://www.ncbi.nlm.nih.gov/pubmed/25948104 http://dx.doi.org/10.1186/s12885-015-1337-3

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