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Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis
BACKGROUND: The best clinical practice to investigate aerobic fitness includes measurements obtained during cardiopulmonary exercise testing (CPET), however it remains an underutilised clinical measure in cystic fibrosis (CF). To investigate this further, different methods of quantifying exercise ca...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430900/ https://www.ncbi.nlm.nih.gov/pubmed/25952747 http://dx.doi.org/10.1186/s12890-015-0036-9 |
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author | Savi, Daniela Di Paolo, Marcello Simmonds, Nicholas Onorati, Paolo Internullo, Mattia Quattrucci, Serena Winston, Banya Laveneziana, Pierantonio Palange, Paolo |
author_facet | Savi, Daniela Di Paolo, Marcello Simmonds, Nicholas Onorati, Paolo Internullo, Mattia Quattrucci, Serena Winston, Banya Laveneziana, Pierantonio Palange, Paolo |
author_sort | Savi, Daniela |
collection | PubMed |
description | BACKGROUND: The best clinical practice to investigate aerobic fitness includes measurements obtained during cardiopulmonary exercise testing (CPET), however it remains an underutilised clinical measure in cystic fibrosis (CF). To investigate this further, different methods of quantifying exercise capacity in CF are required. The possibility that measuring physical activity (PA) by a portable accelerometer could be used to assess the CF aerobic state and could be added among the CPET surrogates has not been investigated. The aim of this study was to examine the relationship between PA and exercise fitness both at submaximal and maximal levels in clinically stable adults with CF. METHODS: Thirty CF patients (FEV(1) 71 ± 19% predicted) and fifteen healthy controls undertook an incremental CPET on a cycle ergometer. CPET-related measurements included: oxygen uptake (V’O(2)), carbon dioxide production (V’CO(2)), ventilatory profile, heart rate (HR) and oxygen pulse (V’O(2)/HR) throughout exercise and at lactic threshold (LT) and peak. LT measures represent submaximal exercise related data. PA was assessed using the accelerometer SenseWear Pro3 Armband. RESULTS: Moderate (>4.8 metabolic equivalents (METS)) and moderate + vigorous (>7.2 METS) PA was related to V’O(2) (p = 0.005 and p = 0.009, respectively) and work rate (p = 0.004 and p = 0.002, respectively) at LT. Moderate PA or greater was positively related to peak V’O(2) (p = 0.005 and p = 0.003, respectively). Daily PA levels were similar in CF and healthy controls. Except for peak values, V’O(2) profile and the V’O(2) at LT were comparable between CF and healthy controls. CONCLUSIONS: In adult CF patients daily PA positively correlated with aerobic capacity. PA measurements are a valuable tool in the assessment of exercise performance in an adult CF population and could be used for interventional exercise trials to optimize exercise performance and health status. PA levels and parameters obtained at submaximal exercise are similar in CF and in healthy controls. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12890-015-0036-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4430900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44309002015-05-15 Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis Savi, Daniela Di Paolo, Marcello Simmonds, Nicholas Onorati, Paolo Internullo, Mattia Quattrucci, Serena Winston, Banya Laveneziana, Pierantonio Palange, Paolo BMC Pulm Med Research Article BACKGROUND: The best clinical practice to investigate aerobic fitness includes measurements obtained during cardiopulmonary exercise testing (CPET), however it remains an underutilised clinical measure in cystic fibrosis (CF). To investigate this further, different methods of quantifying exercise capacity in CF are required. The possibility that measuring physical activity (PA) by a portable accelerometer could be used to assess the CF aerobic state and could be added among the CPET surrogates has not been investigated. The aim of this study was to examine the relationship between PA and exercise fitness both at submaximal and maximal levels in clinically stable adults with CF. METHODS: Thirty CF patients (FEV(1) 71 ± 19% predicted) and fifteen healthy controls undertook an incremental CPET on a cycle ergometer. CPET-related measurements included: oxygen uptake (V’O(2)), carbon dioxide production (V’CO(2)), ventilatory profile, heart rate (HR) and oxygen pulse (V’O(2)/HR) throughout exercise and at lactic threshold (LT) and peak. LT measures represent submaximal exercise related data. PA was assessed using the accelerometer SenseWear Pro3 Armband. RESULTS: Moderate (>4.8 metabolic equivalents (METS)) and moderate + vigorous (>7.2 METS) PA was related to V’O(2) (p = 0.005 and p = 0.009, respectively) and work rate (p = 0.004 and p = 0.002, respectively) at LT. Moderate PA or greater was positively related to peak V’O(2) (p = 0.005 and p = 0.003, respectively). Daily PA levels were similar in CF and healthy controls. Except for peak values, V’O(2) profile and the V’O(2) at LT were comparable between CF and healthy controls. CONCLUSIONS: In adult CF patients daily PA positively correlated with aerobic capacity. PA measurements are a valuable tool in the assessment of exercise performance in an adult CF population and could be used for interventional exercise trials to optimize exercise performance and health status. PA levels and parameters obtained at submaximal exercise are similar in CF and in healthy controls. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12890-015-0036-9) contains supplementary material, which is available to authorized users. BioMed Central 2015-05-09 /pmc/articles/PMC4430900/ /pubmed/25952747 http://dx.doi.org/10.1186/s12890-015-0036-9 Text en © Savi et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Savi, Daniela Di Paolo, Marcello Simmonds, Nicholas Onorati, Paolo Internullo, Mattia Quattrucci, Serena Winston, Banya Laveneziana, Pierantonio Palange, Paolo Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis |
title | Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis |
title_full | Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis |
title_fullStr | Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis |
title_full_unstemmed | Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis |
title_short | Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis |
title_sort | relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430900/ https://www.ncbi.nlm.nih.gov/pubmed/25952747 http://dx.doi.org/10.1186/s12890-015-0036-9 |
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