Cargando…

Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis

BACKGROUND: The best clinical practice to investigate aerobic fitness includes measurements obtained during cardiopulmonary exercise testing (CPET), however it remains an underutilised clinical measure in cystic fibrosis (CF). To investigate this further, different methods of quantifying exercise ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Savi, Daniela, Di Paolo, Marcello, Simmonds, Nicholas, Onorati, Paolo, Internullo, Mattia, Quattrucci, Serena, Winston, Banya, Laveneziana, Pierantonio, Palange, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430900/
https://www.ncbi.nlm.nih.gov/pubmed/25952747
http://dx.doi.org/10.1186/s12890-015-0036-9
_version_ 1782371248499589120
author Savi, Daniela
Di Paolo, Marcello
Simmonds, Nicholas
Onorati, Paolo
Internullo, Mattia
Quattrucci, Serena
Winston, Banya
Laveneziana, Pierantonio
Palange, Paolo
author_facet Savi, Daniela
Di Paolo, Marcello
Simmonds, Nicholas
Onorati, Paolo
Internullo, Mattia
Quattrucci, Serena
Winston, Banya
Laveneziana, Pierantonio
Palange, Paolo
author_sort Savi, Daniela
collection PubMed
description BACKGROUND: The best clinical practice to investigate aerobic fitness includes measurements obtained during cardiopulmonary exercise testing (CPET), however it remains an underutilised clinical measure in cystic fibrosis (CF). To investigate this further, different methods of quantifying exercise capacity in CF are required. The possibility that measuring physical activity (PA) by a portable accelerometer could be used to assess the CF aerobic state and could be added among the CPET surrogates has not been investigated. The aim of this study was to examine the relationship between PA and exercise fitness both at submaximal and maximal levels in clinically stable adults with CF. METHODS: Thirty CF patients (FEV(1) 71 ± 19% predicted) and fifteen healthy controls undertook an incremental CPET on a cycle ergometer. CPET-related measurements included: oxygen uptake (V’O(2)), carbon dioxide production (V’CO(2)), ventilatory profile, heart rate (HR) and oxygen pulse (V’O(2)/HR) throughout exercise and at lactic threshold (LT) and peak. LT measures represent submaximal exercise related data. PA was assessed using the accelerometer SenseWear Pro3 Armband. RESULTS: Moderate (>4.8 metabolic equivalents (METS)) and moderate + vigorous (>7.2 METS) PA was related to V’O(2) (p = 0.005 and p = 0.009, respectively) and work rate (p = 0.004 and p = 0.002, respectively) at LT. Moderate PA or greater was positively related to peak V’O(2) (p = 0.005 and p = 0.003, respectively). Daily PA levels were similar in CF and healthy controls. Except for peak values, V’O(2) profile and the V’O(2) at LT were comparable between CF and healthy controls. CONCLUSIONS: In adult CF patients daily PA positively correlated with aerobic capacity. PA measurements are a valuable tool in the assessment of exercise performance in an adult CF population and could be used for interventional exercise trials to optimize exercise performance and health status. PA levels and parameters obtained at submaximal exercise are similar in CF and in healthy controls. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12890-015-0036-9) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-4430900
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-44309002015-05-15 Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis Savi, Daniela Di Paolo, Marcello Simmonds, Nicholas Onorati, Paolo Internullo, Mattia Quattrucci, Serena Winston, Banya Laveneziana, Pierantonio Palange, Paolo BMC Pulm Med Research Article BACKGROUND: The best clinical practice to investigate aerobic fitness includes measurements obtained during cardiopulmonary exercise testing (CPET), however it remains an underutilised clinical measure in cystic fibrosis (CF). To investigate this further, different methods of quantifying exercise capacity in CF are required. The possibility that measuring physical activity (PA) by a portable accelerometer could be used to assess the CF aerobic state and could be added among the CPET surrogates has not been investigated. The aim of this study was to examine the relationship between PA and exercise fitness both at submaximal and maximal levels in clinically stable adults with CF. METHODS: Thirty CF patients (FEV(1) 71 ± 19% predicted) and fifteen healthy controls undertook an incremental CPET on a cycle ergometer. CPET-related measurements included: oxygen uptake (V’O(2)), carbon dioxide production (V’CO(2)), ventilatory profile, heart rate (HR) and oxygen pulse (V’O(2)/HR) throughout exercise and at lactic threshold (LT) and peak. LT measures represent submaximal exercise related data. PA was assessed using the accelerometer SenseWear Pro3 Armband. RESULTS: Moderate (>4.8 metabolic equivalents (METS)) and moderate + vigorous (>7.2 METS) PA was related to V’O(2) (p = 0.005 and p = 0.009, respectively) and work rate (p = 0.004 and p = 0.002, respectively) at LT. Moderate PA or greater was positively related to peak V’O(2) (p = 0.005 and p = 0.003, respectively). Daily PA levels were similar in CF and healthy controls. Except for peak values, V’O(2) profile and the V’O(2) at LT were comparable between CF and healthy controls. CONCLUSIONS: In adult CF patients daily PA positively correlated with aerobic capacity. PA measurements are a valuable tool in the assessment of exercise performance in an adult CF population and could be used for interventional exercise trials to optimize exercise performance and health status. PA levels and parameters obtained at submaximal exercise are similar in CF and in healthy controls. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12890-015-0036-9) contains supplementary material, which is available to authorized users. BioMed Central 2015-05-09 /pmc/articles/PMC4430900/ /pubmed/25952747 http://dx.doi.org/10.1186/s12890-015-0036-9 Text en © Savi et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Savi, Daniela
Di Paolo, Marcello
Simmonds, Nicholas
Onorati, Paolo
Internullo, Mattia
Quattrucci, Serena
Winston, Banya
Laveneziana, Pierantonio
Palange, Paolo
Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis
title Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis
title_full Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis
title_fullStr Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis
title_full_unstemmed Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis
title_short Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis
title_sort relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430900/
https://www.ncbi.nlm.nih.gov/pubmed/25952747
http://dx.doi.org/10.1186/s12890-015-0036-9
work_keys_str_mv AT savidaniela relationshipbetweendailyphysicalactivityandaerobicfitnessinadultswithcysticfibrosis
AT dipaolomarcello relationshipbetweendailyphysicalactivityandaerobicfitnessinadultswithcysticfibrosis
AT simmondsnicholas relationshipbetweendailyphysicalactivityandaerobicfitnessinadultswithcysticfibrosis
AT onoratipaolo relationshipbetweendailyphysicalactivityandaerobicfitnessinadultswithcysticfibrosis
AT internullomattia relationshipbetweendailyphysicalactivityandaerobicfitnessinadultswithcysticfibrosis
AT quattrucciserena relationshipbetweendailyphysicalactivityandaerobicfitnessinadultswithcysticfibrosis
AT winstonbanya relationshipbetweendailyphysicalactivityandaerobicfitnessinadultswithcysticfibrosis
AT lavenezianapierantonio relationshipbetweendailyphysicalactivityandaerobicfitnessinadultswithcysticfibrosis
AT palangepaolo relationshipbetweendailyphysicalactivityandaerobicfitnessinadultswithcysticfibrosis