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Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria

BACKGROUND: Small Rho-GTPases are critical mediators of neuronal plasticity and are involved in the pathogenesis of several psychiatric and neurological disorders. Rac-GTPase forms a multiprotein complex with upstream and downstream regulators that are essential for the spatiotemporal transmission o...

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Detalles Bibliográficos
Autores principales: Natsvlishvili, Nino, Goguadze, Nino, Zhuravliova, Elene, Mikeladze, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430930/
https://www.ncbi.nlm.nih.gov/pubmed/25924612
http://dx.doi.org/10.1186/s12858-015-0040-y