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Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation
Spermatogonial stem cells (SSCs), the stem cells responsible for male fertility, are one of a small number of cells with the abilities of both self-renewal and generation of large numbers of haploid cells. Technology improvements, most importantly, transplantation assays and in vitro culture systems...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430931/ https://www.ncbi.nlm.nih.gov/pubmed/25657085 http://dx.doi.org/10.4103/1008-682X.148080 |
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author | Mei, Xing-Xing Wang, Jian Wu, Ji |
author_facet | Mei, Xing-Xing Wang, Jian Wu, Ji |
author_sort | Mei, Xing-Xing |
collection | PubMed |
description | Spermatogonial stem cells (SSCs), the stem cells responsible for male fertility, are one of a small number of cells with the abilities of both self-renewal and generation of large numbers of haploid cells. Technology improvements, most importantly, transplantation assays and in vitro culture systems have greatly expanded our understanding of SSC self-renewal and differentiation. Many important molecules crucial for the balance between self-renewal and differentiation have been recently identified although the exact mechanism(s) remain largely undefined. In this review, we give a brief introduction to SSCs, and then focus on extrinsic and intrinsic factors controlling SSCs self-renewal and differentiation. |
format | Online Article Text |
id | pubmed-4430931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44309312015-06-01 Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation Mei, Xing-Xing Wang, Jian Wu, Ji Asian J Androl Invited Review Spermatogonial stem cells (SSCs), the stem cells responsible for male fertility, are one of a small number of cells with the abilities of both self-renewal and generation of large numbers of haploid cells. Technology improvements, most importantly, transplantation assays and in vitro culture systems have greatly expanded our understanding of SSC self-renewal and differentiation. Many important molecules crucial for the balance between self-renewal and differentiation have been recently identified although the exact mechanism(s) remain largely undefined. In this review, we give a brief introduction to SSCs, and then focus on extrinsic and intrinsic factors controlling SSCs self-renewal and differentiation. Medknow Publications & Media Pvt Ltd 2015 2015-02-03 /pmc/articles/PMC4430931/ /pubmed/25657085 http://dx.doi.org/10.4103/1008-682X.148080 Text en Copyright: © Asian Journal of Andrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Review Mei, Xing-Xing Wang, Jian Wu, Ji Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation |
title | Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation |
title_full | Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation |
title_fullStr | Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation |
title_full_unstemmed | Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation |
title_short | Extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation |
title_sort | extrinsic and intrinsic factors controlling spermatogonial stem cell self-renewal and differentiation |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430931/ https://www.ncbi.nlm.nih.gov/pubmed/25657085 http://dx.doi.org/10.4103/1008-682X.148080 |
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