Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9

BACKGROUND: The therapeutic efficacy of arsenic trioxide (As(2)O(3)) in acute myeloid leukemia (AML) is modest, which is partly related to its limited intracellular uptake into the leukemic cells. As(2)O(3) enters cells via the transmembrane protein aquaglyceroporin 9 (AQP9). Azacytidine, a demethyl...

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Detalles Bibliográficos
Autores principales: Chau, David, Ng, Karen, Chan, Thomas Sau-Yan, Cheng, Yuen-Yee, Fong, Bonnie, Tam, Sidney, Kwong, Yok-Lam, Tse, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431177/
https://www.ncbi.nlm.nih.gov/pubmed/25953102
http://dx.doi.org/10.1186/s13045-015-0143-3

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