Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome

BACKGROUND: Collectin-K1 (CL-K1, or CL-11) is a multifunctional Ca(2+)-dependent lectin with roles in innate immunity, apoptosis and embryogenesis. It binds to carbohydrates on pathogens to activate the lectin pathway of complement and together with its associated serine protease MASP-3 serves as a...

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Detalles Bibliográficos
Autores principales: Venkatraman Girija, Umakhanth, Furze, Christopher M, Gingras, Alexandre R, Yoshizaki, Takayuki, Ohtani, Katsuki, Marshall, Jamie E, Wallis, A Katrine, Schwaeble, Wilhelm J, El-Mezgueldi, Mohammed, Mitchell, Daniel A, Moody, Peter CE, Wakamiya, Nobutaka, Wallis, Russell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431178/
https://www.ncbi.nlm.nih.gov/pubmed/25912189
http://dx.doi.org/10.1186/s12915-015-0136-2

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