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Noise-robust recognition of wide-field motion direction and the underlying neural mechanisms in Drosophila melanogaster

Appropriate and robust behavioral control in a noisy environment is important for the survival of most organisms. Understanding such robust behavioral control has been an attractive subject in neuroscience research. Here, we investigated the processing of wide-field motion with random dot noise at b...

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Autores principales: Suzuki, Yoshinori, Ikeda, Hideaki, Miyamoto, Takuya, Miyakawa, Hiroyoshi, Seki, Yoichi, Aonishi, Toru, Morimoto, Takako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431354/
https://www.ncbi.nlm.nih.gov/pubmed/25974721
http://dx.doi.org/10.1038/srep10253
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author Suzuki, Yoshinori
Ikeda, Hideaki
Miyamoto, Takuya
Miyakawa, Hiroyoshi
Seki, Yoichi
Aonishi, Toru
Morimoto, Takako
author_facet Suzuki, Yoshinori
Ikeda, Hideaki
Miyamoto, Takuya
Miyakawa, Hiroyoshi
Seki, Yoichi
Aonishi, Toru
Morimoto, Takako
author_sort Suzuki, Yoshinori
collection PubMed
description Appropriate and robust behavioral control in a noisy environment is important for the survival of most organisms. Understanding such robust behavioral control has been an attractive subject in neuroscience research. Here, we investigated the processing of wide-field motion with random dot noise at both the behavioral and neuronal level in Drosophila melanogaster. We measured the head yaw optomotor response (OMR) and the activity of motion-sensitive neurons, horizontal system (HS) cells, with in vivo whole-cell patch clamp recordings at various levels of noise intensity. We found that flies had a robust sensation of motion direction under noisy conditions, while membrane potential changes of HS cells were not correlated with behavioral responses. By applying signal classification theory to the distributions of HS cell responses, however, we found that motion direction under noise can be clearly discriminated by HS cells, and that this discrimination performance was quantitatively similar to that of OMR. Furthermore, we successfully reproduced HS cell activity in response to noisy motion stimuli with a local motion detector model including a spatial filter and threshold function. This study provides evidence for the physiological basis of noise-robust behavior in a tiny insect brain.
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spelling pubmed-44313542015-05-22 Noise-robust recognition of wide-field motion direction and the underlying neural mechanisms in Drosophila melanogaster Suzuki, Yoshinori Ikeda, Hideaki Miyamoto, Takuya Miyakawa, Hiroyoshi Seki, Yoichi Aonishi, Toru Morimoto, Takako Sci Rep Article Appropriate and robust behavioral control in a noisy environment is important for the survival of most organisms. Understanding such robust behavioral control has been an attractive subject in neuroscience research. Here, we investigated the processing of wide-field motion with random dot noise at both the behavioral and neuronal level in Drosophila melanogaster. We measured the head yaw optomotor response (OMR) and the activity of motion-sensitive neurons, horizontal system (HS) cells, with in vivo whole-cell patch clamp recordings at various levels of noise intensity. We found that flies had a robust sensation of motion direction under noisy conditions, while membrane potential changes of HS cells were not correlated with behavioral responses. By applying signal classification theory to the distributions of HS cell responses, however, we found that motion direction under noise can be clearly discriminated by HS cells, and that this discrimination performance was quantitatively similar to that of OMR. Furthermore, we successfully reproduced HS cell activity in response to noisy motion stimuli with a local motion detector model including a spatial filter and threshold function. This study provides evidence for the physiological basis of noise-robust behavior in a tiny insect brain. Nature Publishing Group 2015-05-14 /pmc/articles/PMC4431354/ /pubmed/25974721 http://dx.doi.org/10.1038/srep10253 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Suzuki, Yoshinori
Ikeda, Hideaki
Miyamoto, Takuya
Miyakawa, Hiroyoshi
Seki, Yoichi
Aonishi, Toru
Morimoto, Takako
Noise-robust recognition of wide-field motion direction and the underlying neural mechanisms in Drosophila melanogaster
title Noise-robust recognition of wide-field motion direction and the underlying neural mechanisms in Drosophila melanogaster
title_full Noise-robust recognition of wide-field motion direction and the underlying neural mechanisms in Drosophila melanogaster
title_fullStr Noise-robust recognition of wide-field motion direction and the underlying neural mechanisms in Drosophila melanogaster
title_full_unstemmed Noise-robust recognition of wide-field motion direction and the underlying neural mechanisms in Drosophila melanogaster
title_short Noise-robust recognition of wide-field motion direction and the underlying neural mechanisms in Drosophila melanogaster
title_sort noise-robust recognition of wide-field motion direction and the underlying neural mechanisms in drosophila melanogaster
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431354/
https://www.ncbi.nlm.nih.gov/pubmed/25974721
http://dx.doi.org/10.1038/srep10253
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