Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a devastating late onset neurodegenerative disorder that is characterised by the progressive loss of upper and lower motor neurons. The mechanisms underlying ALS pathogenesis are unclear; however, there is emerging evidence the innate immune system,...

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Detalles Bibliográficos
Autores principales: Lee, Jia Y, Lee, John D, Phipps, Simon, Noakes, Peter G, Woodruff, Trent M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431460/
https://www.ncbi.nlm.nih.gov/pubmed/25962427
http://dx.doi.org/10.1186/s12974-015-0310-z

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