Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

Tau is a central player in Alzheimer's disease (AD) and related Tauopathies, where it is found as aggregates in degenerating neurons. Abnormal post-translational modifications, such as truncation, are likely involved in the pathological process. A major step forward in understanding the role of...

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Detalles Bibliográficos
Autores principales: Derisbourg, Maxime, Leghay, Coline, Chiappetta, Giovanni, Fernandez-Gomez, Francisco-Jose, Laurent, Cyril, Demeyer, Dominique, Carrier, Sébastien, Buée-Scherrer, Valérie, Blum, David, Vinh, Joëlle, Sergeant, Nicolas, Verdier, Yann, Buée, Luc, Hamdane, Malika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431475/
https://www.ncbi.nlm.nih.gov/pubmed/25974414
http://dx.doi.org/10.1038/srep09659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431475/
https://www.ncbi.nlm.nih.gov/pubmed/25974414
http://dx.doi.org/10.1038/srep09659

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