A pilot study of acotiamide hydrochloride hydrate in patients with detrusor underactivity

AIM: To investigate the clinical efficacy of acotiamide hydrochloride hydrate in patients with detrusor underactivity. METHODS: We measured the post-void residual urinary volume in 19 patients with underactive bladders. All these patients had been under treatment with distigmine bromide and were pre...

Descripción completa

Detalles Bibliográficos
Autores principales: Sugimoto, Koichi, Akiyama, Takahiro, Shimizu, Nobutaka, Matsumura, Naoki, Hayashi, Taiji, Nishioka, Tsukasa, Uemura, Hirotsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431496/
https://www.ncbi.nlm.nih.gov/pubmed/26056686
http://dx.doi.org/10.2147/RRU.S83309
_version_ 1782371363450781696
author Sugimoto, Koichi
Akiyama, Takahiro
Shimizu, Nobutaka
Matsumura, Naoki
Hayashi, Taiji
Nishioka, Tsukasa
Uemura, Hirotsugu
author_facet Sugimoto, Koichi
Akiyama, Takahiro
Shimizu, Nobutaka
Matsumura, Naoki
Hayashi, Taiji
Nishioka, Tsukasa
Uemura, Hirotsugu
author_sort Sugimoto, Koichi
collection PubMed
description AIM: To investigate the clinical efficacy of acotiamide hydrochloride hydrate in patients with detrusor underactivity. METHODS: We measured the post-void residual urinary volume in 19 patients with underactive bladders. All these patients had been under treatment with distigmine bromide and were prescribed acotiamide hydrochloride hydrate at a dose of 100 mg three times daily for 2 weeks. RESULTS: Compared with the post-void residual urinary volume value at baseline (161.4±90.0 mL) a statistically significant reduction was observed at the end of treatment (116.3±63.1 mL) (P=0.006). The drug was generally well tolerated by the majority of patients. CONCLUSION: Maybe, acotiamide hydrochloride hydrate showed clinical efficacy in patients with underactive bladders and may, therefore, be used alternatively in patients who do not respond sufficiently to distigmine bromide.
format Online
Article
Text
id pubmed-4431496
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-44314962015-06-08 A pilot study of acotiamide hydrochloride hydrate in patients with detrusor underactivity Sugimoto, Koichi Akiyama, Takahiro Shimizu, Nobutaka Matsumura, Naoki Hayashi, Taiji Nishioka, Tsukasa Uemura, Hirotsugu Res Rep Urol Original Research AIM: To investigate the clinical efficacy of acotiamide hydrochloride hydrate in patients with detrusor underactivity. METHODS: We measured the post-void residual urinary volume in 19 patients with underactive bladders. All these patients had been under treatment with distigmine bromide and were prescribed acotiamide hydrochloride hydrate at a dose of 100 mg three times daily for 2 weeks. RESULTS: Compared with the post-void residual urinary volume value at baseline (161.4±90.0 mL) a statistically significant reduction was observed at the end of treatment (116.3±63.1 mL) (P=0.006). The drug was generally well tolerated by the majority of patients. CONCLUSION: Maybe, acotiamide hydrochloride hydrate showed clinical efficacy in patients with underactive bladders and may, therefore, be used alternatively in patients who do not respond sufficiently to distigmine bromide. Dove Medical Press 2015-05-08 /pmc/articles/PMC4431496/ /pubmed/26056686 http://dx.doi.org/10.2147/RRU.S83309 Text en © 2015 Sugimoto et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Sugimoto, Koichi
Akiyama, Takahiro
Shimizu, Nobutaka
Matsumura, Naoki
Hayashi, Taiji
Nishioka, Tsukasa
Uemura, Hirotsugu
A pilot study of acotiamide hydrochloride hydrate in patients with detrusor underactivity
title A pilot study of acotiamide hydrochloride hydrate in patients with detrusor underactivity
title_full A pilot study of acotiamide hydrochloride hydrate in patients with detrusor underactivity
title_fullStr A pilot study of acotiamide hydrochloride hydrate in patients with detrusor underactivity
title_full_unstemmed A pilot study of acotiamide hydrochloride hydrate in patients with detrusor underactivity
title_short A pilot study of acotiamide hydrochloride hydrate in patients with detrusor underactivity
title_sort pilot study of acotiamide hydrochloride hydrate in patients with detrusor underactivity
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431496/
https://www.ncbi.nlm.nih.gov/pubmed/26056686
http://dx.doi.org/10.2147/RRU.S83309
work_keys_str_mv AT sugimotokoichi apilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity
AT akiyamatakahiro apilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity
AT shimizunobutaka apilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity
AT matsumuranaoki apilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity
AT hayashitaiji apilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity
AT nishiokatsukasa apilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity
AT uemurahirotsugu apilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity
AT sugimotokoichi pilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity
AT akiyamatakahiro pilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity
AT shimizunobutaka pilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity
AT matsumuranaoki pilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity
AT hayashitaiji pilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity
AT nishiokatsukasa pilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity
AT uemurahirotsugu pilotstudyofacotiamidehydrochloridehydrateinpatientswithdetrusorunderactivity

Ejemplares similares