Mic10 Oligomerization Pinches off Mitochondrial Cristae

The mitochondrial contact site and cristae organizing system (MICOS) complex is essential for normal mitochondria biogenesis and morphology. In this issue, Bohnert et al. (2015) and Barbot et al. (2015) demonstrate that a MICOS core subunit, Mic10, is crucial for mitochondrial cristae formation by f...

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Detalles Bibliográficos
Autores principales: Milenkovic, Dusanka, Larsson, Nils-Göran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431669/
https://www.ncbi.nlm.nih.gov/pubmed/25955201
http://dx.doi.org/10.1016/j.cmet.2015.04.020
Descripción
Sumario:The mitochondrial contact site and cristae organizing system (MICOS) complex is essential for normal mitochondria biogenesis and morphology. In this issue, Bohnert et al. (2015) and Barbot et al. (2015) demonstrate that a MICOS core subunit, Mic10, is crucial for mitochondrial cristae formation by forming oligomers at the cristae junctions.

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