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Higher BMI is associated with reduced brain volume in heart failure

BACKGROUND: Heart failure (HF) patients are at risk for structural brain changes due to cerebral hypoperfusion. Past work shows obesity is linked with reduced cerebral blood flow and associated with brain atrophy in healthy individuals, although its effects on the brain in HF are unclear. This study...

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Autores principales: Alosco, Michael L, Brickman, Adam M, Spitznagel, Mary Beth, Narkhede, Atul, Griffith, Erica Y, Raz, Naftali, Cohen, Ronald, Sweet, Lawrence H, Colbert, Lisa H, Josephson, Richard, Hughes, Joel, Rosneck, Jim, Gunstad, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431695/
https://www.ncbi.nlm.nih.gov/pubmed/25984353
http://dx.doi.org/10.1186/2052-9538-1-4
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author Alosco, Michael L
Brickman, Adam M
Spitznagel, Mary Beth
Narkhede, Atul
Griffith, Erica Y
Raz, Naftali
Cohen, Ronald
Sweet, Lawrence H
Colbert, Lisa H
Josephson, Richard
Hughes, Joel
Rosneck, Jim
Gunstad, John
author_facet Alosco, Michael L
Brickman, Adam M
Spitznagel, Mary Beth
Narkhede, Atul
Griffith, Erica Y
Raz, Naftali
Cohen, Ronald
Sweet, Lawrence H
Colbert, Lisa H
Josephson, Richard
Hughes, Joel
Rosneck, Jim
Gunstad, John
author_sort Alosco, Michael L
collection PubMed
description BACKGROUND: Heart failure (HF) patients are at risk for structural brain changes due to cerebral hypoperfusion. Past work shows obesity is linked with reduced cerebral blood flow and associated with brain atrophy in healthy individuals, although its effects on the brain in HF are unclear. This study examined the association among body mass index (BMI), cerebral perfusion, and brain volume in HF patients. RESULTS: Eighty HF patients underwent transcranial Doppler sonography to quantify cerebral blood flow velocity of the middle cerebral artery (CBF-V of the MCA) and brain magnetic resonance imaging (MRI) to quantify total brain, total and subcortical gray matter, white matter volume, and white matter hyperintensities. Body mass index (BMI) operationalized weight status. Nearly 45% of HF patients exhibited a BMI consistent with obesity. Regression analyses adjusting for medical variables, demographic characteristics, and CBF-V of the MCA, showed increased BMI was associated with reduced white matter volume (p < .05). BMI also interacted with cerebral perfusion to impact total gray matter volume, but this pattern did not emerge for any other MRI indices (p < 0.05). CONCLUSIONS: Our findings suggest increased BMI negatively affects brain volume in HF, and higher BMI interacts with cerebral perfusion to impact gray matter volume. The mechanisms for these findings remain unclear and likely involve multiple physiological processes. Prospective studies are needed to elucidate the exact pattern and rates of brain changes in obese HF persons.
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spelling pubmed-44316952015-05-14 Higher BMI is associated with reduced brain volume in heart failure Alosco, Michael L Brickman, Adam M Spitznagel, Mary Beth Narkhede, Atul Griffith, Erica Y Raz, Naftali Cohen, Ronald Sweet, Lawrence H Colbert, Lisa H Josephson, Richard Hughes, Joel Rosneck, Jim Gunstad, John BMC Obes Research Article BACKGROUND: Heart failure (HF) patients are at risk for structural brain changes due to cerebral hypoperfusion. Past work shows obesity is linked with reduced cerebral blood flow and associated with brain atrophy in healthy individuals, although its effects on the brain in HF are unclear. This study examined the association among body mass index (BMI), cerebral perfusion, and brain volume in HF patients. RESULTS: Eighty HF patients underwent transcranial Doppler sonography to quantify cerebral blood flow velocity of the middle cerebral artery (CBF-V of the MCA) and brain magnetic resonance imaging (MRI) to quantify total brain, total and subcortical gray matter, white matter volume, and white matter hyperintensities. Body mass index (BMI) operationalized weight status. Nearly 45% of HF patients exhibited a BMI consistent with obesity. Regression analyses adjusting for medical variables, demographic characteristics, and CBF-V of the MCA, showed increased BMI was associated with reduced white matter volume (p < .05). BMI also interacted with cerebral perfusion to impact total gray matter volume, but this pattern did not emerge for any other MRI indices (p < 0.05). CONCLUSIONS: Our findings suggest increased BMI negatively affects brain volume in HF, and higher BMI interacts with cerebral perfusion to impact gray matter volume. The mechanisms for these findings remain unclear and likely involve multiple physiological processes. Prospective studies are needed to elucidate the exact pattern and rates of brain changes in obese HF persons. BioMed Central 2014-02-19 /pmc/articles/PMC4431695/ /pubmed/25984353 http://dx.doi.org/10.1186/2052-9538-1-4 Text en © Alosco et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Alosco, Michael L
Brickman, Adam M
Spitznagel, Mary Beth
Narkhede, Atul
Griffith, Erica Y
Raz, Naftali
Cohen, Ronald
Sweet, Lawrence H
Colbert, Lisa H
Josephson, Richard
Hughes, Joel
Rosneck, Jim
Gunstad, John
Higher BMI is associated with reduced brain volume in heart failure
title Higher BMI is associated with reduced brain volume in heart failure
title_full Higher BMI is associated with reduced brain volume in heart failure
title_fullStr Higher BMI is associated with reduced brain volume in heart failure
title_full_unstemmed Higher BMI is associated with reduced brain volume in heart failure
title_short Higher BMI is associated with reduced brain volume in heart failure
title_sort higher bmi is associated with reduced brain volume in heart failure
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431695/
https://www.ncbi.nlm.nih.gov/pubmed/25984353
http://dx.doi.org/10.1186/2052-9538-1-4
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