Diagnosis and Treatment of Pancreas Rejection

Despite significant improvement in pancreas allograft survival, rejection of the pancreas remains a major clinical problem. In addition to cellular rejection of the pancreas, antibody-mediated rejection of the pancreas is now a well-described entity. The 2011 Banff update established comprehensive g...

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Detalles Bibliográficos
Autores principales: Redfield, R. R., Kaufman, D. B., Odorico, J. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Pancreas Transplantation (DA Axelrod, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431702/
https://www.ncbi.nlm.nih.gov/pubmed/26000231
http://dx.doi.org/10.1007/s40472-015-0061-x
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author Redfield, R. R.
Kaufman, D. B.
Odorico, J. S.
author_facet Redfield, R. R.
Kaufman, D. B.
Odorico, J. S.
author_sort Redfield, R. R.
collection PubMed
description Despite significant improvement in pancreas allograft survival, rejection of the pancreas remains a major clinical problem. In addition to cellular rejection of the pancreas, antibody-mediated rejection of the pancreas is now a well-described entity. The 2011 Banff update established comprehensive guidelines for the diagnosis of acute and chronic AMR. The pancreas biopsy is critical in order to accurately diagnose and treat pancreas rejection. Other modes of monitoring pancreas rejection we feel are neither sensitive nor specific enough. In this review, we examine recent advances in the diagnosis and treatment of pancreas rejection as well as describe practical diagnostic and treatment algorithms.
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spelling pubmed-44317022015-05-19 Diagnosis and Treatment of Pancreas Rejection Redfield, R. R. Kaufman, D. B. Odorico, J. S. Curr Transplant Rep Pancreas Transplantation (DA Axelrod, Section Editor) Despite significant improvement in pancreas allograft survival, rejection of the pancreas remains a major clinical problem. In addition to cellular rejection of the pancreas, antibody-mediated rejection of the pancreas is now a well-described entity. The 2011 Banff update established comprehensive guidelines for the diagnosis of acute and chronic AMR. The pancreas biopsy is critical in order to accurately diagnose and treat pancreas rejection. Other modes of monitoring pancreas rejection we feel are neither sensitive nor specific enough. In this review, we examine recent advances in the diagnosis and treatment of pancreas rejection as well as describe practical diagnostic and treatment algorithms. Springer International Publishing 2015-04-11 2015 /pmc/articles/PMC4431702/ /pubmed/26000231 http://dx.doi.org/10.1007/s40472-015-0061-x Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Pancreas Transplantation (DA Axelrod, Section Editor)
Redfield, R. R.
Kaufman, D. B.
Odorico, J. S.
Diagnosis and Treatment of Pancreas Rejection
title Diagnosis and Treatment of Pancreas Rejection
title_full Diagnosis and Treatment of Pancreas Rejection
title_fullStr Diagnosis and Treatment of Pancreas Rejection
title_full_unstemmed Diagnosis and Treatment of Pancreas Rejection
title_short Diagnosis and Treatment of Pancreas Rejection
title_sort diagnosis and treatment of pancreas rejection
topic Pancreas Transplantation (DA Axelrod, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431702/
https://www.ncbi.nlm.nih.gov/pubmed/26000231
http://dx.doi.org/10.1007/s40472-015-0061-x
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