Early Lineage Priming by Trisomy of Erg Leads to Myeloproliferation in a Down Syndrome Model

Down syndrome (DS), with trisomy of chromosome 21 (HSA21), is the commonest human aneuploidy. Pre-leukemic myeloproliferative changes in DS foetal livers precede the acquisition of GATA1 mutations, transient myeloproliferative disorder (DS-TMD) and acute megakaryocytic leukemia (DS-AMKL). Trisomy of...

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Detalles Bibliográficos
Autores principales: Ng, Ashley P., Hu, Yifang, Metcalf, Donald, Hyland, Craig D., Ierino, Helen, Phipson, Belinda, Wu, Di, Baldwin, Tracey M., Kauppi, Maria, Kiu, Hiu, Di Rago, Ladina, Hilton, Douglas J., Smyth, Gordon K., Alexander, Warren S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431731/
https://www.ncbi.nlm.nih.gov/pubmed/25973911
http://dx.doi.org/10.1371/journal.pgen.1005211

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