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Antimicrobial Air Filters Using Natural Euscaphis japonica Nanoparticles

Controlling bioaerosols has become more important with increasing participation in indoor activities. Treatments using natural-product nanomaterials are a promising technique because of their relatively low toxicity compared to inorganic nanomaterials such as silver nanoparticles or carbon nanotubes...

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Autores principales: Hwang, Gi Byoung, Heo, Ki Joon, Yun, Ji Ho, Lee, Jung Eun, Lee, Hee Ju, Nho, Chu Won, Bae, Gwi- Nam, Jung, Jae Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431859/
https://www.ncbi.nlm.nih.gov/pubmed/25974109
http://dx.doi.org/10.1371/journal.pone.0126481
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author Hwang, Gi Byoung
Heo, Ki Joon
Yun, Ji Ho
Lee, Jung Eun
Lee, Hee Ju
Nho, Chu Won
Bae, Gwi- Nam
Jung, Jae Hee
author_facet Hwang, Gi Byoung
Heo, Ki Joon
Yun, Ji Ho
Lee, Jung Eun
Lee, Hee Ju
Nho, Chu Won
Bae, Gwi- Nam
Jung, Jae Hee
author_sort Hwang, Gi Byoung
collection PubMed
description Controlling bioaerosols has become more important with increasing participation in indoor activities. Treatments using natural-product nanomaterials are a promising technique because of their relatively low toxicity compared to inorganic nanomaterials such as silver nanoparticles or carbon nanotubes. In this study, antimicrobial filters were fabricated from natural Euscaphis japonica nanoparticles, which were produced by nebulizing E. japonica extract. The coated filters were assessed in terms of pressure drop, antimicrobial activity, filtration efficiency, major chemical components, and cytotoxicity. Pressure drop and antimicrobial activity increased as a function of nanoparticle deposition time (590, 855, and 1150 µg/cm2(filter) at 3-, 6-, and 9-min depositions, respectively). In filter tests, the antimicrobial efficacy was greater against Staphylococcus epidermidis than Micrococcus luteus; ~61, ~73, and ~82% of M. luteus cells were inactivated on filters that had been coated for 3, 6, and 9 min, respectively, while the corresponding values were ~78, ~88, and ~94% with S. epidermidis. Although statistically significant differences in filtration performance were not observed between samples as a function of deposition time, the average filtration efficacy was slightly higher for S. epidermidis aerosols (~97%) than for M. luteus aerosols (~95%). High-performance liquid chromatography (HPLC) and electrospray ionization-tandem mass spectrometry (ESI/MS) analyses confirmed that the major chemical compounds in the E. japonica extract were 1(ß)-O-galloyl pedunculagin, quercetin-3-O-glucuronide, and kaempferol-3-O-glucoside. In vitro cytotoxicity and disk diffusion tests showed that E. japonica nanoparticles were less toxic and exhibited stronger antimicrobial activity toward some bacterial strains than a reference soluble nickel compound, which is classified as a human carcinogen. This study provides valuable information for the development of a bioaerosol control system that is environmental friendly and suitable for use in indoor environments.
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spelling pubmed-44318592015-05-27 Antimicrobial Air Filters Using Natural Euscaphis japonica Nanoparticles Hwang, Gi Byoung Heo, Ki Joon Yun, Ji Ho Lee, Jung Eun Lee, Hee Ju Nho, Chu Won Bae, Gwi- Nam Jung, Jae Hee PLoS One Research Article Controlling bioaerosols has become more important with increasing participation in indoor activities. Treatments using natural-product nanomaterials are a promising technique because of their relatively low toxicity compared to inorganic nanomaterials such as silver nanoparticles or carbon nanotubes. In this study, antimicrobial filters were fabricated from natural Euscaphis japonica nanoparticles, which were produced by nebulizing E. japonica extract. The coated filters were assessed in terms of pressure drop, antimicrobial activity, filtration efficiency, major chemical components, and cytotoxicity. Pressure drop and antimicrobial activity increased as a function of nanoparticle deposition time (590, 855, and 1150 µg/cm2(filter) at 3-, 6-, and 9-min depositions, respectively). In filter tests, the antimicrobial efficacy was greater against Staphylococcus epidermidis than Micrococcus luteus; ~61, ~73, and ~82% of M. luteus cells were inactivated on filters that had been coated for 3, 6, and 9 min, respectively, while the corresponding values were ~78, ~88, and ~94% with S. epidermidis. Although statistically significant differences in filtration performance were not observed between samples as a function of deposition time, the average filtration efficacy was slightly higher for S. epidermidis aerosols (~97%) than for M. luteus aerosols (~95%). High-performance liquid chromatography (HPLC) and electrospray ionization-tandem mass spectrometry (ESI/MS) analyses confirmed that the major chemical compounds in the E. japonica extract were 1(ß)-O-galloyl pedunculagin, quercetin-3-O-glucuronide, and kaempferol-3-O-glucoside. In vitro cytotoxicity and disk diffusion tests showed that E. japonica nanoparticles were less toxic and exhibited stronger antimicrobial activity toward some bacterial strains than a reference soluble nickel compound, which is classified as a human carcinogen. This study provides valuable information for the development of a bioaerosol control system that is environmental friendly and suitable for use in indoor environments. Public Library of Science 2015-05-14 /pmc/articles/PMC4431859/ /pubmed/25974109 http://dx.doi.org/10.1371/journal.pone.0126481 Text en © 2015 Hwang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hwang, Gi Byoung
Heo, Ki Joon
Yun, Ji Ho
Lee, Jung Eun
Lee, Hee Ju
Nho, Chu Won
Bae, Gwi- Nam
Jung, Jae Hee
Antimicrobial Air Filters Using Natural Euscaphis japonica Nanoparticles
title Antimicrobial Air Filters Using Natural Euscaphis japonica Nanoparticles
title_full Antimicrobial Air Filters Using Natural Euscaphis japonica Nanoparticles
title_fullStr Antimicrobial Air Filters Using Natural Euscaphis japonica Nanoparticles
title_full_unstemmed Antimicrobial Air Filters Using Natural Euscaphis japonica Nanoparticles
title_short Antimicrobial Air Filters Using Natural Euscaphis japonica Nanoparticles
title_sort antimicrobial air filters using natural euscaphis japonica nanoparticles
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431859/
https://www.ncbi.nlm.nih.gov/pubmed/25974109
http://dx.doi.org/10.1371/journal.pone.0126481
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