A Novel Gene Amplification Causes Upregulation of the PatAB ABC Transporter and Fluoroquinolone Resistance in Streptococcus pneumoniae

Overexpression of the ABC transporter genes patA and patB confers efflux-mediated fluoroquinolone resistance in Streptococcus pneumoniae and is also linked to pneumococcal stress responses. Although upregulation of patAB has been observed in many laboratory mutants and clinical isolates, the regulat...

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Detalles Bibliográficos
Autores principales: Baylay, Alison J., Ivens, Alasdair, Piddock, Laura J. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432121/
https://www.ncbi.nlm.nih.gov/pubmed/25779578
http://dx.doi.org/10.1128/AAC.04858-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432121/
https://www.ncbi.nlm.nih.gov/pubmed/25779578
http://dx.doi.org/10.1128/AAC.04858-14

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