Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment

Heavy-chain deposition disease (HCDD) is the least common of the monoclonal immunoglobulin deposition diseases with only 24 reported cases in English literature, including the present case. The rarity of this disease merits its documentation. We present a case of HCDD from our archival material, who...

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Autores principales: Rane, Swapnil, Rana, Seema, Mudrabettu, Chetan, Jha, Vivekananda, Joshi, Kusum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Original Contributions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432403/
https://www.ncbi.nlm.nih.gov/pubmed/26019812
http://dx.doi.org/10.1093/ckj/sfs062
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author Rane, Swapnil
Rana, Seema
Mudrabettu, Chetan
Jha, Vivekananda
Joshi, Kusum
author_facet Rane, Swapnil
Rana, Seema
Mudrabettu, Chetan
Jha, Vivekananda
Joshi, Kusum
author_sort Rane, Swapnil
collection PubMed
description Heavy-chain deposition disease (HCDD) is the least common of the monoclonal immunoglobulin deposition diseases with only 24 reported cases in English literature, including the present case. The rarity of this disease merits its documentation. We present a case of HCDD from our archival material, who presented with rapidly progressive renal failure and nephrotic syndrome and was found to have nodular glomerulosclerosis on renal biopsy which on immunofluorescence and electron microscopy confirmed HCDD of immunoglobulin G1 type without any light-chain deposition. We also present an in-depth literature review on HCDD.
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spelling pubmed-44324032015-05-27 Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment Rane, Swapnil Rana, Seema Mudrabettu, Chetan Jha, Vivekananda Joshi, Kusum Clin Kidney J Original Contributions Heavy-chain deposition disease (HCDD) is the least common of the monoclonal immunoglobulin deposition diseases with only 24 reported cases in English literature, including the present case. The rarity of this disease merits its documentation. We present a case of HCDD from our archival material, who presented with rapidly progressive renal failure and nephrotic syndrome and was found to have nodular glomerulosclerosis on renal biopsy which on immunofluorescence and electron microscopy confirmed HCDD of immunoglobulin G1 type without any light-chain deposition. We also present an in-depth literature review on HCDD. Oxford University Press 2012-10 /pmc/articles/PMC4432403/ /pubmed/26019812 http://dx.doi.org/10.1093/ckj/sfs062 Text en © The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Contributions
Rane, Swapnil
Rana, Seema
Mudrabettu, Chetan
Jha, Vivekananda
Joshi, Kusum
Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment
title Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment
title_full Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment
title_fullStr Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment
title_full_unstemmed Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment
title_short Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment
title_sort heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432403/
https://www.ncbi.nlm.nih.gov/pubmed/26019812
http://dx.doi.org/10.1093/ckj/sfs062
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AT ranaseema heavychaindepositiondiseaseamorphologicalimmunofluorescenceandultrastructuralassessment
AT mudrabettuchetan heavychaindepositiondiseaseamorphologicalimmunofluorescenceandultrastructuralassessment
AT jhavivekananda heavychaindepositiondiseaseamorphologicalimmunofluorescenceandultrastructuralassessment
AT joshikusum heavychaindepositiondiseaseamorphologicalimmunofluorescenceandultrastructuralassessment

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