Discrete renal deposition of IgM heavy chain and κ light chain in Waldenström macroglobulinemia (IgM-κ)

We report previously undescribed renal lesions associated with monoclonal gammopathy in a 59-year-old man with Waldenström macroglobulinemia (IgM-κ). Light microscopy showed mesangial proliferation and thickening of glomerular basement membranes (GBMs) and tubular basement membranes (TBMs). Neither...

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Autores principales: Komatsuda, Atsushi, Masai, Rie, Togashi, Masaru, Ohtani, Hiroshi, Sawada, Kenichi, Wakui, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Clinical Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432407/
https://www.ncbi.nlm.nih.gov/pubmed/26019823
http://dx.doi.org/10.1093/ckj/sfs088
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author Komatsuda, Atsushi
Masai, Rie
Togashi, Masaru
Ohtani, Hiroshi
Sawada, Kenichi
Wakui, Hideki
author_facet Komatsuda, Atsushi
Masai, Rie
Togashi, Masaru
Ohtani, Hiroshi
Sawada, Kenichi
Wakui, Hideki
author_sort Komatsuda, Atsushi
collection PubMed
description We report previously undescribed renal lesions associated with monoclonal gammopathy in a 59-year-old man with Waldenström macroglobulinemia (IgM-κ). Light microscopy showed mesangial proliferation and thickening of glomerular basement membranes (GBMs) and tubular basement membranes (TBMs). Neither intraglomerular thrombi nor nodular glomerulosclerosis was observed. Immunofluorescence studies disclosed essentially discrete localization of IgM heavy chain within the mesangial area and κ light chain along GBMs and TBMs. Electron microscopy showed continuous linear deposits of finely granular electron-dense material along the inner aspect of GBMs and TBMs. Repeated rituximab treatment and chemotherapy (melphalan and prednisolone) led to the improvement of proteinuria.
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spelling pubmed-44324072015-05-27 Discrete renal deposition of IgM heavy chain and κ light chain in Waldenström macroglobulinemia (IgM-κ) Komatsuda, Atsushi Masai, Rie Togashi, Masaru Ohtani, Hiroshi Sawada, Kenichi Wakui, Hideki Clin Kidney J Clinical Cases We report previously undescribed renal lesions associated with monoclonal gammopathy in a 59-year-old man with Waldenström macroglobulinemia (IgM-κ). Light microscopy showed mesangial proliferation and thickening of glomerular basement membranes (GBMs) and tubular basement membranes (TBMs). Neither intraglomerular thrombi nor nodular glomerulosclerosis was observed. Immunofluorescence studies disclosed essentially discrete localization of IgM heavy chain within the mesangial area and κ light chain along GBMs and TBMs. Electron microscopy showed continuous linear deposits of finely granular electron-dense material along the inner aspect of GBMs and TBMs. Repeated rituximab treatment and chemotherapy (melphalan and prednisolone) led to the improvement of proteinuria. Oxford University Press 2012-10 /pmc/articles/PMC4432407/ /pubmed/26019823 http://dx.doi.org/10.1093/ckj/sfs088 Text en © The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please email: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Cases
Komatsuda, Atsushi
Masai, Rie
Togashi, Masaru
Ohtani, Hiroshi
Sawada, Kenichi
Wakui, Hideki
Discrete renal deposition of IgM heavy chain and κ light chain in Waldenström macroglobulinemia (IgM-κ)
title Discrete renal deposition of IgM heavy chain and κ light chain in Waldenström macroglobulinemia (IgM-κ)
title_full Discrete renal deposition of IgM heavy chain and κ light chain in Waldenström macroglobulinemia (IgM-κ)
title_fullStr Discrete renal deposition of IgM heavy chain and κ light chain in Waldenström macroglobulinemia (IgM-κ)
title_full_unstemmed Discrete renal deposition of IgM heavy chain and κ light chain in Waldenström macroglobulinemia (IgM-κ)
title_short Discrete renal deposition of IgM heavy chain and κ light chain in Waldenström macroglobulinemia (IgM-κ)
title_sort discrete renal deposition of igm heavy chain and κ light chain in waldenström macroglobulinemia (igm-κ)
topic Clinical Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432407/
https://www.ncbi.nlm.nih.gov/pubmed/26019823
http://dx.doi.org/10.1093/ckj/sfs088
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