Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol

BACKGROUND: Na/K-ATPase (NKA) is inhibited by perillyl alcohol (POH), a monoterpene used in the treatment of tumors, including brain tumors. The NKA α(1) subunit is known to be superexpressed in glioblastoma cells (GBM). This isoform is embedded in caveolar structures and is probably responsible for...

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Detalles Bibliográficos
Autores principales: Garcia, Diogo Gomes, Castro-Faria-Neto, Hugo Caire de, Silva, Camila Ignácio da, Souza e Souza, Kauê Francisco Correa de, Gonçalves-de-Albuquerque, Cassiano Felippe, Silva, Adriana Ribeiro, Amorim, Lidia Maria da Fonte de, Freire, Aline Soares, Santelli, Ricardo Erthal, Diniz, Luan Pereira, Gomes, Flávia Carvalho Alcantara, Faria, Mauro Velho de Castro, Burth, Patrícia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432499/
https://www.ncbi.nlm.nih.gov/pubmed/25976744
http://dx.doi.org/10.1186/s12943-015-0374-5

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