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What are the macrophages and stellate cells doing in pancreatic adenocarcinoma?
Pancreatic ductal adenocarcinoma is a devastating disease characterized by a dense desmoplastic stroma. Chemo- and radio-therapeutic strategies based on targeting cancer cells have failed in improving the outcome of this cancer suggesting important roles for stroma in therapy resistance. Cells in th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432577/ https://www.ncbi.nlm.nih.gov/pubmed/26029109 http://dx.doi.org/10.3389/fphys.2015.00125 |
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author | Pandol, Stephen J. Edderkaoui, Mouad |
author_facet | Pandol, Stephen J. Edderkaoui, Mouad |
author_sort | Pandol, Stephen J. |
collection | PubMed |
description | Pancreatic ductal adenocarcinoma is a devastating disease characterized by a dense desmoplastic stroma. Chemo- and radio-therapeutic strategies based on targeting cancer cells have failed in improving the outcome of this cancer suggesting important roles for stroma in therapy resistance. Cells in the tumor stroma have been shown to regulate proliferation, resistance to apoptosis and treatments, epithelial to mesenchymal transition (EMT) and stemness of cancer cells. Stellate cells in their activated state have been thought over the past decade to only have tumor promoting roles. However, recent findings suggest that stellate cells may have protective roles as well. The present review highlights the latest findings on the role of two major components of tumor stroma, pancreatic stellate cells and macrophages, in promoting or inhibiting pancreatic cancer, focused on their effects on EMT and cancer stemness. |
format | Online Article Text |
id | pubmed-4432577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44325772015-05-29 What are the macrophages and stellate cells doing in pancreatic adenocarcinoma? Pandol, Stephen J. Edderkaoui, Mouad Front Physiol Physiology Pancreatic ductal adenocarcinoma is a devastating disease characterized by a dense desmoplastic stroma. Chemo- and radio-therapeutic strategies based on targeting cancer cells have failed in improving the outcome of this cancer suggesting important roles for stroma in therapy resistance. Cells in the tumor stroma have been shown to regulate proliferation, resistance to apoptosis and treatments, epithelial to mesenchymal transition (EMT) and stemness of cancer cells. Stellate cells in their activated state have been thought over the past decade to only have tumor promoting roles. However, recent findings suggest that stellate cells may have protective roles as well. The present review highlights the latest findings on the role of two major components of tumor stroma, pancreatic stellate cells and macrophages, in promoting or inhibiting pancreatic cancer, focused on their effects on EMT and cancer stemness. Frontiers Media S.A. 2015-05-15 /pmc/articles/PMC4432577/ /pubmed/26029109 http://dx.doi.org/10.3389/fphys.2015.00125 Text en Copyright © 2015 Pandol and Edderkaoui. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Pandol, Stephen J. Edderkaoui, Mouad What are the macrophages and stellate cells doing in pancreatic adenocarcinoma? |
title | What are the macrophages and stellate cells doing in pancreatic adenocarcinoma? |
title_full | What are the macrophages and stellate cells doing in pancreatic adenocarcinoma? |
title_fullStr | What are the macrophages and stellate cells doing in pancreatic adenocarcinoma? |
title_full_unstemmed | What are the macrophages and stellate cells doing in pancreatic adenocarcinoma? |
title_short | What are the macrophages and stellate cells doing in pancreatic adenocarcinoma? |
title_sort | what are the macrophages and stellate cells doing in pancreatic adenocarcinoma? |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432577/ https://www.ncbi.nlm.nih.gov/pubmed/26029109 http://dx.doi.org/10.3389/fphys.2015.00125 |
work_keys_str_mv | AT pandolstephenj whatarethemacrophagesandstellatecellsdoinginpancreaticadenocarcinoma AT edderkaouimouad whatarethemacrophagesandstellatecellsdoinginpancreaticadenocarcinoma |