Cargando…
Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain
The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruc...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432642/ https://www.ncbi.nlm.nih.gov/pubmed/25960343 http://dx.doi.org/10.1038/ncomms8119 |
_version_ | 1782371519522930688 |
---|---|
author | Eldholm, Vegard Monteserin, Johana Rieux, Adrien Lopez, Beatriz Sobkowiak, Benjamin Ritacco, Viviana Balloux, Francois |
author_facet | Eldholm, Vegard Monteserin, Johana Rieux, Adrien Lopez, Beatriz Sobkowiak, Benjamin Ritacco, Viviana Balloux, Francois |
author_sort | Eldholm, Vegard |
collection | PubMed |
description | The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired resistance to isoniazid, streptomycin and rifampicin by around 1973, indicating continuous circulation of a multidrug-resistant TB strain for four decades. By around 1979 the strain had acquired additional resistance to three more drugs. Our results indicate that Mycobacterium tuberculosis (Mtb) with extensive resistance profiles circulated 15 years before the outbreak was detected, and about one decade before the earliest documented transmission of Mtb strains with such extensive resistance profiles globally. |
format | Online Article Text |
id | pubmed-4432642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44326422015-05-23 Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain Eldholm, Vegard Monteserin, Johana Rieux, Adrien Lopez, Beatriz Sobkowiak, Benjamin Ritacco, Viviana Balloux, Francois Nat Commun Article The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired resistance to isoniazid, streptomycin and rifampicin by around 1973, indicating continuous circulation of a multidrug-resistant TB strain for four decades. By around 1979 the strain had acquired additional resistance to three more drugs. Our results indicate that Mycobacterium tuberculosis (Mtb) with extensive resistance profiles circulated 15 years before the outbreak was detected, and about one decade before the earliest documented transmission of Mtb strains with such extensive resistance profiles globally. Nature Pub. Group 2015-05-11 /pmc/articles/PMC4432642/ /pubmed/25960343 http://dx.doi.org/10.1038/ncomms8119 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Eldholm, Vegard Monteserin, Johana Rieux, Adrien Lopez, Beatriz Sobkowiak, Benjamin Ritacco, Viviana Balloux, Francois Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain |
title | Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain |
title_full | Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain |
title_fullStr | Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain |
title_full_unstemmed | Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain |
title_short | Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain |
title_sort | four decades of transmission of a multidrug-resistant mycobacterium tuberculosis outbreak strain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432642/ https://www.ncbi.nlm.nih.gov/pubmed/25960343 http://dx.doi.org/10.1038/ncomms8119 |
work_keys_str_mv | AT eldholmvegard fourdecadesoftransmissionofamultidrugresistantmycobacteriumtuberculosisoutbreakstrain AT monteserinjohana fourdecadesoftransmissionofamultidrugresistantmycobacteriumtuberculosisoutbreakstrain AT rieuxadrien fourdecadesoftransmissionofamultidrugresistantmycobacteriumtuberculosisoutbreakstrain AT lopezbeatriz fourdecadesoftransmissionofamultidrugresistantmycobacteriumtuberculosisoutbreakstrain AT sobkowiakbenjamin fourdecadesoftransmissionofamultidrugresistantmycobacteriumtuberculosisoutbreakstrain AT ritaccoviviana fourdecadesoftransmissionofamultidrugresistantmycobacteriumtuberculosisoutbreakstrain AT ballouxfrancois fourdecadesoftransmissionofamultidrugresistantmycobacteriumtuberculosisoutbreakstrain |