Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation

Protein O-glycosylation is controlled by polypeptide GalNAc-transferases (GalNAc-Ts) that uniquely feature both a catalytic and lectin domain. The underlying molecular basis of how the lectin domains of GalNAc-Ts contribute to glycopeptide specificity and catalysis remains unclear. Here we present t...

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Detalles Bibliográficos
Autores principales: Lira-Navarrete, Erandi, de las Rivas, Matilde, Compañón, Ismael, Pallarés, María Carmen, Kong, Yun, Iglesias-Fernández, Javier, Bernardes, Gonçalo J. L., Peregrina, Jesús M., Rovira, Carme, Bernadó, Pau, Bruscolini, Pierpaolo, Clausen, Henrik, Lostao, Anabel, Corzana, Francisco, Hurtado-Guerrero, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432651/
https://www.ncbi.nlm.nih.gov/pubmed/25939779
http://dx.doi.org/10.1038/ncomms7937

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