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Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF)
Ready-to-use therapeutic foods (RUTFs) are a key component of a life-saving treatment for young children who present with uncomplicated severe acute malnutrition in resource limited settings. Increasing recognition of the role of balanced dietary omega-6 and omega-3 polyunsaturated fatty acids (PUFA...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433071/ https://www.ncbi.nlm.nih.gov/pubmed/25980919 http://dx.doi.org/10.1186/s12916-015-0352-1 |
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author | Brenna, J Thomas Akomo, Peter Bahwere, Paluku Berkley, James A Calder, Philip C Jones, Kelsey D Liu, Lei Manary, Mark Trehan, Indi Briend, André |
author_facet | Brenna, J Thomas Akomo, Peter Bahwere, Paluku Berkley, James A Calder, Philip C Jones, Kelsey D Liu, Lei Manary, Mark Trehan, Indi Briend, André |
author_sort | Brenna, J Thomas |
collection | PubMed |
description | Ready-to-use therapeutic foods (RUTFs) are a key component of a life-saving treatment for young children who present with uncomplicated severe acute malnutrition in resource limited settings. Increasing recognition of the role of balanced dietary omega-6 and omega-3 polyunsaturated fatty acids (PUFA) in neurocognitive and immune development led two independent groups to evaluate RUTFs. Jones et al. (BMC Med 13:93, 2015), in a study in BMC Medicine, and Hsieh et al. (J Pediatr Gastroenterol Nutr 2015), in a study in the Journal of Pediatric Gastroenterology and Nutrition, reformulated RUTFs with altered PUFA content and looked at the effects on circulating omega-3 docosahexaenoic acid (DHA) status as a measure of overall omega-3 status. Supplemental oral administration of omega-3 DHA or reduction of RUTF omega-6 linoleic acid using high oleic peanuts improved DHA status, whereas increasing omega-3 alpha-linolenic acid in RUTF did not. The results of these two small studies are consistent with well-established effects in animal studies and highlight the need for basic and operational research to improve fat composition in support of omega-3-specific development in young children as RUTF use expands. Please see related article: http://www.biomedcentral.com/1741-7015/13/93 |
format | Online Article Text |
id | pubmed-4433071 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44330712015-05-16 Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) Brenna, J Thomas Akomo, Peter Bahwere, Paluku Berkley, James A Calder, Philip C Jones, Kelsey D Liu, Lei Manary, Mark Trehan, Indi Briend, André BMC Med Commentary Ready-to-use therapeutic foods (RUTFs) are a key component of a life-saving treatment for young children who present with uncomplicated severe acute malnutrition in resource limited settings. Increasing recognition of the role of balanced dietary omega-6 and omega-3 polyunsaturated fatty acids (PUFA) in neurocognitive and immune development led two independent groups to evaluate RUTFs. Jones et al. (BMC Med 13:93, 2015), in a study in BMC Medicine, and Hsieh et al. (J Pediatr Gastroenterol Nutr 2015), in a study in the Journal of Pediatric Gastroenterology and Nutrition, reformulated RUTFs with altered PUFA content and looked at the effects on circulating omega-3 docosahexaenoic acid (DHA) status as a measure of overall omega-3 status. Supplemental oral administration of omega-3 DHA or reduction of RUTF omega-6 linoleic acid using high oleic peanuts improved DHA status, whereas increasing omega-3 alpha-linolenic acid in RUTF did not. The results of these two small studies are consistent with well-established effects in animal studies and highlight the need for basic and operational research to improve fat composition in support of omega-3-specific development in young children as RUTF use expands. Please see related article: http://www.biomedcentral.com/1741-7015/13/93 BioMed Central 2015-05-15 /pmc/articles/PMC4433071/ /pubmed/25980919 http://dx.doi.org/10.1186/s12916-015-0352-1 Text en © Brenna et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Commentary Brenna, J Thomas Akomo, Peter Bahwere, Paluku Berkley, James A Calder, Philip C Jones, Kelsey D Liu, Lei Manary, Mark Trehan, Indi Briend, André Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) |
title | Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) |
title_full | Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) |
title_fullStr | Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) |
title_full_unstemmed | Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) |
title_short | Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF) |
title_sort | balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (rutf) |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433071/ https://www.ncbi.nlm.nih.gov/pubmed/25980919 http://dx.doi.org/10.1186/s12916-015-0352-1 |
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