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The Clinical and Socio-Economic Relevance of Increased IPMN Detection Rates and Management Choices

BACKGROUND: Increased usage of computed tomography and magnetic resonance imaging has led to a large increase in identified pancreatic cysts of up to 25% in population-based studies. The clinical and economic relevance of identifying so many cystic lesions has not been established. Compared to other...

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Autores principales: Budde, Christoph, Beyer, Georg, Kühn, Jens-Peter, Lerch, Markus M., Mayerle, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger Verlag für Medizin und Naturwissenschaften GmbH 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433134/
https://www.ncbi.nlm.nih.gov/pubmed/26286668
http://dx.doi.org/10.1159/000375455
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author Budde, Christoph
Beyer, Georg
Kühn, Jens-Peter
Lerch, Markus M.
Mayerle, Julia
author_facet Budde, Christoph
Beyer, Georg
Kühn, Jens-Peter
Lerch, Markus M.
Mayerle, Julia
author_sort Budde, Christoph
collection PubMed
description BACKGROUND: Increased usage of computed tomography and magnetic resonance imaging has led to a large increase in identified pancreatic cysts of up to 25% in population-based studies. The clinical and economic relevance of identifying so many cystic lesions has not been established. Compared to other organs such as liver or kidney, dysontogenetic pancreatic cysts are rare. Pancreatic cysts comprise a variety of benign, premalignant or malignant lesions; however, precise diagnosis before resection has an accuracy of only 80%. The focus of recent research was the malignant potential of intraductal papillary mucinous neoplasms (IPMN) with the aim of establishing clinical pathways addressing risk of malignancy, age and comorbidity, treatment-related morbidity and mortality as well as cost-effectiveness of treatment and surveillance. The focus of this review is to analyze the clinical and socio-economic relevance as well as the cost-benefit relation for IPMNs. METHODS: For analysis, the following MESH terms were used to identify original articles, reviews, and guidelines in PubMed: (‘intraductal papillary mucinous neoplasm’ OR ‘pancreatic cysts’) and (incidence OR relevance OR socio-economic OR economic OR cost-effectiveness OR cost-benefit). The retrieved publications were reviewed with a focus on clinical and socio-economic relevance in relation to the increasing incidence of IPMN. RESULTS: Addressing the increasing prevalence of pancreatic cystic lesions, recent consensus guidelines suggested criteria for risk stratification according to ‘worrisome features’ and ‘high-risk stigmata’. Recent prospective cohort studies evaluated whether these can be applied in clinical practice. Evaluation of three different clinical scenarios with regard to costs and quality-adjusted life years suggested a better effectiveness of surveillance after initial risk stratification by endoscopic ultrasound-guided fine-needle aspiration with cyst fluid analysis compared with immediate resection or follow-up without further intervention. Of interest, the ‘immediate surgery’ strategy was lowest for cost-effectiveness. CONCLUSIONS: The increasing incidence of identified pancreatic cysts requires an improved strategy for non-invasive risk stratification based on advanced imaging strategies. In light of a malignancy risk of 2% for branch-duct IPMN, the socio-economic necessity of a balance between surveillance and resection has to be agreed on.
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spelling pubmed-44331342016-02-01 The Clinical and Socio-Economic Relevance of Increased IPMN Detection Rates and Management Choices Budde, Christoph Beyer, Georg Kühn, Jens-Peter Lerch, Markus M. Mayerle, Julia Viszeralmedizin Review Article BACKGROUND: Increased usage of computed tomography and magnetic resonance imaging has led to a large increase in identified pancreatic cysts of up to 25% in population-based studies. The clinical and economic relevance of identifying so many cystic lesions has not been established. Compared to other organs such as liver or kidney, dysontogenetic pancreatic cysts are rare. Pancreatic cysts comprise a variety of benign, premalignant or malignant lesions; however, precise diagnosis before resection has an accuracy of only 80%. The focus of recent research was the malignant potential of intraductal papillary mucinous neoplasms (IPMN) with the aim of establishing clinical pathways addressing risk of malignancy, age and comorbidity, treatment-related morbidity and mortality as well as cost-effectiveness of treatment and surveillance. The focus of this review is to analyze the clinical and socio-economic relevance as well as the cost-benefit relation for IPMNs. METHODS: For analysis, the following MESH terms were used to identify original articles, reviews, and guidelines in PubMed: (‘intraductal papillary mucinous neoplasm’ OR ‘pancreatic cysts’) and (incidence OR relevance OR socio-economic OR economic OR cost-effectiveness OR cost-benefit). The retrieved publications were reviewed with a focus on clinical and socio-economic relevance in relation to the increasing incidence of IPMN. RESULTS: Addressing the increasing prevalence of pancreatic cystic lesions, recent consensus guidelines suggested criteria for risk stratification according to ‘worrisome features’ and ‘high-risk stigmata’. Recent prospective cohort studies evaluated whether these can be applied in clinical practice. Evaluation of three different clinical scenarios with regard to costs and quality-adjusted life years suggested a better effectiveness of surveillance after initial risk stratification by endoscopic ultrasound-guided fine-needle aspiration with cyst fluid analysis compared with immediate resection or follow-up without further intervention. Of interest, the ‘immediate surgery’ strategy was lowest for cost-effectiveness. CONCLUSIONS: The increasing incidence of identified pancreatic cysts requires an improved strategy for non-invasive risk stratification based on advanced imaging strategies. In light of a malignancy risk of 2% for branch-duct IPMN, the socio-economic necessity of a balance between surveillance and resection has to be agreed on. S. Karger Verlag für Medizin und Naturwissenschaften GmbH 2015-02 2015-02-12 /pmc/articles/PMC4433134/ /pubmed/26286668 http://dx.doi.org/10.1159/000375455 Text en Copyright © 2015 by S. Karger GmbH, Freiburg
spellingShingle Review Article
Budde, Christoph
Beyer, Georg
Kühn, Jens-Peter
Lerch, Markus M.
Mayerle, Julia
The Clinical and Socio-Economic Relevance of Increased IPMN Detection Rates and Management Choices
title The Clinical and Socio-Economic Relevance of Increased IPMN Detection Rates and Management Choices
title_full The Clinical and Socio-Economic Relevance of Increased IPMN Detection Rates and Management Choices
title_fullStr The Clinical and Socio-Economic Relevance of Increased IPMN Detection Rates and Management Choices
title_full_unstemmed The Clinical and Socio-Economic Relevance of Increased IPMN Detection Rates and Management Choices
title_short The Clinical and Socio-Economic Relevance of Increased IPMN Detection Rates and Management Choices
title_sort clinical and socio-economic relevance of increased ipmn detection rates and management choices
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433134/
https://www.ncbi.nlm.nih.gov/pubmed/26286668
http://dx.doi.org/10.1159/000375455
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