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Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals
Psychophysiological markers have been focused to investigate the psychopathology of psychiatric disorders and personality subtypes. In order to understand neurobiological mechanisms underlying these conditions, fear-conditioning model has been widely used. However, simple aversive stimuli are too si...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433209/ https://www.ncbi.nlm.nih.gov/pubmed/25978817 http://dx.doi.org/10.1371/journal.pone.0125729 |
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author | Tada, Mitsuhiro Uchida, Hiroyuki Maeda, Takaki Konishi, Mika Umeda, Satoshi Terasawa, Yuri Nakajima, Shinichiro Mimura, Masaru Miyazaki, Tomoyuki Takahashi, Takuya |
author_facet | Tada, Mitsuhiro Uchida, Hiroyuki Maeda, Takaki Konishi, Mika Umeda, Satoshi Terasawa, Yuri Nakajima, Shinichiro Mimura, Masaru Miyazaki, Tomoyuki Takahashi, Takuya |
author_sort | Tada, Mitsuhiro |
collection | PubMed |
description | Psychophysiological markers have been focused to investigate the psychopathology of psychiatric disorders and personality subtypes. In order to understand neurobiological mechanisms underlying these conditions, fear-conditioning model has been widely used. However, simple aversive stimuli are too simplistic to understand mechanisms because most patients with psychiatric disorders are affected by social stressors. The objective of this study was to test the feasibility of a newly-designed conditioning experiment using a stimulus to cause interpersonal conflicts and examine associations between personality traits and response to that stimulus. Twenty-nine healthy individuals underwent the fear conditioning and extinction experiments in response to three types of stimuli: a simple aversive sound, disgusting pictures, and pictures of an actors’ face with unpleasant verbal messages that were designed to cause interpersonal conflicts. Conditioned response was quantified by the skin conductance response (SCR). Correlations between the SCR changes, and personality traits measured by the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) and Revised NEO Personality Inventory were explored. The interpersonal conflict stimulus resulted in successful conditioning, which was subsequently extinguished, in a similar manner as the other two stimuli. Moreover, a greater degree of conditioned response to the interpersonal conflict stimulus correlated with a higher ZAN-BPD total score. Fear conditioning and extinction can be successfully achieved, using interpersonal conflicts as a stimulus. Given that conditioned fear caused by the interpersonal conflicts is likely associated with borderline personality traits, this paradigm could contribute to further understanding of underlying mechanisms of interpersonal fear implicated in borderline personality disorder. |
format | Online Article Text |
id | pubmed-4433209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44332092015-05-27 Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals Tada, Mitsuhiro Uchida, Hiroyuki Maeda, Takaki Konishi, Mika Umeda, Satoshi Terasawa, Yuri Nakajima, Shinichiro Mimura, Masaru Miyazaki, Tomoyuki Takahashi, Takuya PLoS One Research Article Psychophysiological markers have been focused to investigate the psychopathology of psychiatric disorders and personality subtypes. In order to understand neurobiological mechanisms underlying these conditions, fear-conditioning model has been widely used. However, simple aversive stimuli are too simplistic to understand mechanisms because most patients with psychiatric disorders are affected by social stressors. The objective of this study was to test the feasibility of a newly-designed conditioning experiment using a stimulus to cause interpersonal conflicts and examine associations between personality traits and response to that stimulus. Twenty-nine healthy individuals underwent the fear conditioning and extinction experiments in response to three types of stimuli: a simple aversive sound, disgusting pictures, and pictures of an actors’ face with unpleasant verbal messages that were designed to cause interpersonal conflicts. Conditioned response was quantified by the skin conductance response (SCR). Correlations between the SCR changes, and personality traits measured by the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) and Revised NEO Personality Inventory were explored. The interpersonal conflict stimulus resulted in successful conditioning, which was subsequently extinguished, in a similar manner as the other two stimuli. Moreover, a greater degree of conditioned response to the interpersonal conflict stimulus correlated with a higher ZAN-BPD total score. Fear conditioning and extinction can be successfully achieved, using interpersonal conflicts as a stimulus. Given that conditioned fear caused by the interpersonal conflicts is likely associated with borderline personality traits, this paradigm could contribute to further understanding of underlying mechanisms of interpersonal fear implicated in borderline personality disorder. Public Library of Science 2015-05-15 /pmc/articles/PMC4433209/ /pubmed/25978817 http://dx.doi.org/10.1371/journal.pone.0125729 Text en © 2015 Tada et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Tada, Mitsuhiro Uchida, Hiroyuki Maeda, Takaki Konishi, Mika Umeda, Satoshi Terasawa, Yuri Nakajima, Shinichiro Mimura, Masaru Miyazaki, Tomoyuki Takahashi, Takuya Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals |
title | Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals |
title_full | Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals |
title_fullStr | Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals |
title_full_unstemmed | Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals |
title_short | Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals |
title_sort | fear conditioning induced by interpersonal conflicts in healthy individuals |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433209/ https://www.ncbi.nlm.nih.gov/pubmed/25978817 http://dx.doi.org/10.1371/journal.pone.0125729 |
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