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Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals

Psychophysiological markers have been focused to investigate the psychopathology of psychiatric disorders and personality subtypes. In order to understand neurobiological mechanisms underlying these conditions, fear-conditioning model has been widely used. However, simple aversive stimuli are too si...

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Autores principales: Tada, Mitsuhiro, Uchida, Hiroyuki, Maeda, Takaki, Konishi, Mika, Umeda, Satoshi, Terasawa, Yuri, Nakajima, Shinichiro, Mimura, Masaru, Miyazaki, Tomoyuki, Takahashi, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433209/
https://www.ncbi.nlm.nih.gov/pubmed/25978817
http://dx.doi.org/10.1371/journal.pone.0125729
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author Tada, Mitsuhiro
Uchida, Hiroyuki
Maeda, Takaki
Konishi, Mika
Umeda, Satoshi
Terasawa, Yuri
Nakajima, Shinichiro
Mimura, Masaru
Miyazaki, Tomoyuki
Takahashi, Takuya
author_facet Tada, Mitsuhiro
Uchida, Hiroyuki
Maeda, Takaki
Konishi, Mika
Umeda, Satoshi
Terasawa, Yuri
Nakajima, Shinichiro
Mimura, Masaru
Miyazaki, Tomoyuki
Takahashi, Takuya
author_sort Tada, Mitsuhiro
collection PubMed
description Psychophysiological markers have been focused to investigate the psychopathology of psychiatric disorders and personality subtypes. In order to understand neurobiological mechanisms underlying these conditions, fear-conditioning model has been widely used. However, simple aversive stimuli are too simplistic to understand mechanisms because most patients with psychiatric disorders are affected by social stressors. The objective of this study was to test the feasibility of a newly-designed conditioning experiment using a stimulus to cause interpersonal conflicts and examine associations between personality traits and response to that stimulus. Twenty-nine healthy individuals underwent the fear conditioning and extinction experiments in response to three types of stimuli: a simple aversive sound, disgusting pictures, and pictures of an actors’ face with unpleasant verbal messages that were designed to cause interpersonal conflicts. Conditioned response was quantified by the skin conductance response (SCR). Correlations between the SCR changes, and personality traits measured by the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) and Revised NEO Personality Inventory were explored. The interpersonal conflict stimulus resulted in successful conditioning, which was subsequently extinguished, in a similar manner as the other two stimuli. Moreover, a greater degree of conditioned response to the interpersonal conflict stimulus correlated with a higher ZAN-BPD total score. Fear conditioning and extinction can be successfully achieved, using interpersonal conflicts as a stimulus. Given that conditioned fear caused by the interpersonal conflicts is likely associated with borderline personality traits, this paradigm could contribute to further understanding of underlying mechanisms of interpersonal fear implicated in borderline personality disorder.
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spelling pubmed-44332092015-05-27 Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals Tada, Mitsuhiro Uchida, Hiroyuki Maeda, Takaki Konishi, Mika Umeda, Satoshi Terasawa, Yuri Nakajima, Shinichiro Mimura, Masaru Miyazaki, Tomoyuki Takahashi, Takuya PLoS One Research Article Psychophysiological markers have been focused to investigate the psychopathology of psychiatric disorders and personality subtypes. In order to understand neurobiological mechanisms underlying these conditions, fear-conditioning model has been widely used. However, simple aversive stimuli are too simplistic to understand mechanisms because most patients with psychiatric disorders are affected by social stressors. The objective of this study was to test the feasibility of a newly-designed conditioning experiment using a stimulus to cause interpersonal conflicts and examine associations between personality traits and response to that stimulus. Twenty-nine healthy individuals underwent the fear conditioning and extinction experiments in response to three types of stimuli: a simple aversive sound, disgusting pictures, and pictures of an actors’ face with unpleasant verbal messages that were designed to cause interpersonal conflicts. Conditioned response was quantified by the skin conductance response (SCR). Correlations between the SCR changes, and personality traits measured by the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) and Revised NEO Personality Inventory were explored. The interpersonal conflict stimulus resulted in successful conditioning, which was subsequently extinguished, in a similar manner as the other two stimuli. Moreover, a greater degree of conditioned response to the interpersonal conflict stimulus correlated with a higher ZAN-BPD total score. Fear conditioning and extinction can be successfully achieved, using interpersonal conflicts as a stimulus. Given that conditioned fear caused by the interpersonal conflicts is likely associated with borderline personality traits, this paradigm could contribute to further understanding of underlying mechanisms of interpersonal fear implicated in borderline personality disorder. Public Library of Science 2015-05-15 /pmc/articles/PMC4433209/ /pubmed/25978817 http://dx.doi.org/10.1371/journal.pone.0125729 Text en © 2015 Tada et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tada, Mitsuhiro
Uchida, Hiroyuki
Maeda, Takaki
Konishi, Mika
Umeda, Satoshi
Terasawa, Yuri
Nakajima, Shinichiro
Mimura, Masaru
Miyazaki, Tomoyuki
Takahashi, Takuya
Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals
title Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals
title_full Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals
title_fullStr Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals
title_full_unstemmed Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals
title_short Fear Conditioning Induced by Interpersonal Conflicts in Healthy Individuals
title_sort fear conditioning induced by interpersonal conflicts in healthy individuals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433209/
https://www.ncbi.nlm.nih.gov/pubmed/25978817
http://dx.doi.org/10.1371/journal.pone.0125729
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