Cargando…

A New Family of HEAT-Like Repeat Proteins Lacking a Critical Substrate Recognition Motif Present in Related DNA Glycosylases

DNA glycosylases are important repair enzymes that eliminate a diverse array of aberrant nucleobases from the genomes of all organisms. Individual bacterial species often contain multiple paralogs of a particular glycosylase, yet the molecular and functional distinctions between these paralogs are n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mullins, Elwood A., Shi, Rongxin, Kotsch, Lyle A., Eichman, Brandt F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433238/ https://www.ncbi.nlm.nih.gov/pubmed/25978435 http://dx.doi.org/10.1371/journal.pone.0127733

Ejemplares similares

Toxicity and repair of DNA adducts produced by the natural product yatakemycin
por: Mullins, Elwood A., et al.
Publicado: (2017)

5-Methylcytosine Recognition by Arabidopsis thaliana DNA Glycosylases DEMETER and DML3
por: Brooks, Sonja C., et al.
Publicado: (2014)

Kinetics of substrate recognition and cleavage by human 8-oxoguanine-DNA glycosylase
por: Kuznetsov, Nikita A., et al.
Publicado: (2005)

Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases
por: Bradley, Noah P., et al.
Publicado: (2022)

Escherichia coli YcaQ is a DNA glycosylase that unhooks DNA interstrand crosslinks
por: Bradley, Noah P, et al.
Publicado: (2020)

Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites
por: Mullins, Elwood A., et al.
Publicado: (2021)

Uracil-DNA glycosylase efficiency is modulated by substrate rigidity
por: Orndorff, Paul B., et al.
Publicado: (2023)

Flexibility and distributive synthesis regulate RNA priming and handoff in human DNA polymerase α-primase
por: Cordoba, John J., et al.
Publicado: (2023)

Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats
por: Dalhus, Bjørn, et al.
Publicado: (2007)

Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase
por: Coey, Christopher T, et al.
Publicado: (2018)

Lesion Recognition and Cleavage of Damage-Containing Quadruplexes and Bulged Structures by DNA Glycosylases
por: Kuznetsova, Alexandra A., et al.
Publicado: (2020)

The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase
por: Shigdel, Uddhav K., et al.
Publicado: (2020)

Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation
por: Schomacher, Lars, et al.
Publicado: (2016)

Molecular beacons with oxidized bases report on substrate specificity of DNA oxoguanine glycosylases
por: Sun, Jingjing, et al.
Publicado: (2022)

Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging
por: Buechner, Claudia N., et al.
Publicado: (2015)

Sequence-Specific Intramembrane Proteolysis: Identification of a Recognition Motif in Rhomboid Substrates
por: Strisovsky, Kvido, et al.
Publicado: (2009)

Evaluation of APOBEC3B Recognition Motifs by NMR Reveals Preferred Substrates
por: Liu, Manjuan, et al.
Publicado: (2018)

Active destabilization of base pairs by a DNA glycosylase wedge initiates damage recognition
por: Kuznetsov, Nikita A., et al.
Publicado: (2015)

A Zinc Linchpin Motif in the MUTYH Glycosylase Interdomain Connector Is Required for Efficient Repair of DNA Damage
por: Engstrom, Lisa M., et al.
Publicado: (2014)

A structurally conserved motif in γ-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping
por: Earl, Christopher, et al.
Publicado: (2018)

Effect of DNA Glycosylases OGG1 and Neil1 on Oxidized G-Rich Motif in the KRAS Promoter
por: Ferino, Annalisa, et al.
Publicado: (2021)

T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif
por: Lucey, Marie J., et al.
Publicado: (2005)

Noncatalytic Domains in DNA Glycosylases
por: Torgasheva, Natalia A., et al.
Publicado: (2022)

Characterization of the major formamidopyrimidine–DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats
por: Olsen, Ingrid, et al.
Publicado: (2009)

Thermodynamic and kinetic basis for recognition and repair of 8-oxoguanine in DNA by human 8-oxoguanine-DNA glycosylase
por: Kirpota, Oleg O., et al.
Publicado: (2011)

Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues
por: Coey, Christopher T., et al.
Publicado: (2016)

Inhibitors of DNA Glycosylases as Prospective Drugs
por: Mechetin, Grigory V., et al.
Publicado: (2020)

Mechanisms of glycosylase induced genomic instability
por: Eyler, Daniel E., et al.
Publicado: (2017)

Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats
por: Rafie, Karim, et al.
Publicado: (2017)

Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions
por: Cooper-Knock, Johnathan, et al.
Publicado: (2014)

Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing
por: Franck, Coste, et al.
Publicado: (2022)

Substrate recognition of holocytochrome c synthase: N-terminal region and CXXCH motif of mitochondrial cytochrome c
por: Zhang, Yulin, et al.
Publicado: (2014)

Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability
por: Cilli, Piera, et al.
Publicado: (2016)

The L motifs of two moss pentatricopeptide repeat proteins are involved in RNA editing but predominantly not in RNA recognition
por: Matsuda, Takuya, et al.
Publicado: (2020)

DNA glycosylases: in DNA repair and beyond
por: Jacobs, Angelika L., et al.
Publicado: (2011)

Uracil DNA glycosylase (UDG) activities in Bradyrhizobium diazoefficiens: characterization of a new class of UDG with broad substrate specificity
por: Chembazhi, Ullas Valiya, et al.
Publicado: (2017)

A model for 3-methyladenine recognition by 3-methyladenine DNA glycosylase I (TAG) from Staphylococcus aureus
por: Zhu, Xiaofeng, et al.
Publicado: (2012)

Target search and recognition mechanisms of glycosylase AlkD revealed by scanning FRET-FCS and Markov state models
por: Peng, Sijia, et al.
Publicado: (2020)

Recognition of a tandem lesion by DNA bacterial formamidopyrimidine glycosylases explored combining molecular dynamics and machine learning
por: Bignon, Emmanuelle, et al.
Publicado: (2021)

Importance of extended protease substrate recognition motifs in steering BNIP-2 cleavage by human and mouse granzymes B
por: Van Damme, Petra, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_the9h86p79i71v27u44f8b4hvo