SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure

Null mutations in one copy of ATP2A2, the gene encoding sarco/endoplasmic reticulum Ca(2+)-ATPase isoform 2 (SERCA2), cause Darier disease in humans, a skin condition involving keratinocytes. Cardiac function appears to be unimpaired in Darier disease patients, with no evidence that SERCA2 haploinsu...

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Detalles Bibliográficos
Autores principales: Prasad, Vikram, Lorenz, John N., Lasko, Valerie M., Nieman, Michelle L., Huang, Wei, Wang, Yigang, Wieczorek, David W., Shull, Gary E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433638/
https://www.ncbi.nlm.nih.gov/pubmed/26064889
http://dx.doi.org/10.1155/2015/251598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433638/
https://www.ncbi.nlm.nih.gov/pubmed/26064889
http://dx.doi.org/10.1155/2015/251598

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