Cargando…

SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure

Null mutations in one copy of ATP2A2, the gene encoding sarco/endoplasmic reticulum Ca(2+)-ATPase isoform 2 (SERCA2), cause Darier disease in humans, a skin condition involving keratinocytes. Cardiac function appears to be unimpaired in Darier disease patients, with no evidence that SERCA2 haploinsu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prasad, Vikram, Lorenz, John N., Lasko, Valerie M., Nieman, Michelle L., Huang, Wei, Wang, Yigang, Wieczorek, David W., Shull, Gary E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433638/ https://www.ncbi.nlm.nih.gov/pubmed/26064889 http://dx.doi.org/10.1155/2015/251598

Ejemplares similares

Loss of the AE3 Cl(−)/HCO(−)(3) exchanger in mice affects rate-dependent inotropy and stress-related AKT signaling in heart
por: Prasad, Vikram, et al.
Publicado: (2013)

Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease
por: Zaver, Shivam A., et al.
Publicado: (2023)

Darier's Disease
por: Jamieson, W. Allan
Publicado: (1907)

SUMO1-dependent modulation of SERCA2a in heart failure
por: Kho, Changwon, et al.
Publicado: (2011)

SERCA2a Protein Levels Are Unaltered in Human Heart Failure
por: Ragone, Isabella, et al.
Publicado: (2023)

SERCA2-controlled Ca(2+)-dependent Keratinocyte Adhesion and Differentiation is Mediated via the Sphingolipid Pathway- a Novel Therapeutic Target for Darier’s Disease
por: Celli, Anna, et al.
Publicado: (2012)

Contractile Behavior of Mouse Aorta Depends on SERCA2 Isoform Distribution: Effects of Replacing SERCA2a by SERCA2b
por: Fransen, Paul, et al.
Publicado: (2020)

Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure
por: Kho, Changwon, et al.
Publicado: (2015)

Darier Disease with Psoriasis
por: Kang, Seok-Young, et al.
Publicado: (2022)

Darier disease is associated with heart failure: a cross-sectional case-control and population based study
por: Bachar-Wikstrom, Etty, et al.
Publicado: (2020)

Common genetic predisposition for heart failure and cancer
por: Pfeffer, Tobias J., et al.
Publicado: (2020)

NBCe1 Na(+)-HCO3(-) cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo
por: Vairamani, Kanimozhi, et al.
Publicado: (2018)

Enfermedad de Darier : revisión bibliográfica /
por: Hernández Uscanga, Silvia
Publicado: (1993)

SERCA is critical to control the Bowditch effect in the heart
por: Balcazar, Darío, et al.
Publicado: (2018)

DARIER’S DISEASE WITH PERIFOLLICULAR HYPOPIGMENTATION
por: Sornakumar, L, et al.
Publicado: (2010)

Darier and Ferrand dermatofibrosarcoma of the breast
por: Naqos, Nora
Publicado: (2018)

Dermoscopic Demonstration of Darier Sign
por: Mukherjee, Sweta, et al.
Publicado: (2021)

SERCA2a: a prime target for modulation of cardiac contractility during heart failure
por: Park, Woo Jin, et al.
Publicado: (2013)

Correcting Calcium Dysregulation in Chronic Heart Failure Using SERCA2a Gene Therapy
por: Samuel, T. Jake, et al.
Publicado: (2018)

Improvement in malodor with topical metronidazole gel in Darier disease
por: Michelle, Lauren, et al.
Publicado: (2020)

Solitary mastocytoma with positive Darier's sign
por: Nair, Brijesh, et al.
Publicado: (2016)

Case for diagnosis. Linear Darier's disease
por: Bidoia, Fernanda Del Pintor, et al.
Publicado: (2018)

Darier disease: A rare genodermatosis
por: Suryawanshi, Hema, et al.
Publicado: (2017)

Darier's Disease Appearing as Pityriasis Amiantacea
por: Yang, Min-Young, et al.
Publicado: (2018)

Exacerbation of Darier’s disease with COVID-19
por: Dykes, Rachel, et al.
Publicado: (2022)

Darier's Disease - Response to Oral Vitamin A: Report of a Case and Brief Review
por: Sondhi, Megha, et al.
Publicado: (2020)

Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
por: Røe, Åsmund T, et al.
Publicado: (2019)

Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
por: Dhondup, Yangchen, et al.
Publicado: (2017)

Value of SERCA2a as a Biomarker for the Identification of Patients with Heart Failure Requiring Circulatory Support
por: Ezzitouny, Meryem, et al.
Publicado: (2021)

Genetic predisposition study of heart failure and its association with cardiomyopathy
por: Kaviarasan, Vaishak, et al.
Publicado: (2022)

Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device – the SERCA-LVAD TRIAL
por: Lyon, A. R., et al.
Publicado: (2020)

Measuring SERCA-mediated calcium uptake in mouse muscle homogenates
por: Geromella, Mia S., et al.
Publicado: (2023)

Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation
por: Peri, Suraj, et al.
Publicado: (2016)

Enfermedad de darier : revisión bibliográfica y presentación de un caso clínico /
por: Ortega Serrano, María Teresa
Publicado: (1988)

Understanding the Role of SERCA2a Microdomain Remodeling in Heart Failure Induced by Obesity and Type 2 Diabetes
por: Lai, Ping, et al.
Publicado: (2022)

Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome
por: Campanha, Fábio V. G., et al.
Publicado: (2016)

A Case of Familial Comedonal Darier's Disease
por: Chung, Jimin, et al.
Publicado: (2011)

A Rare Clinical Presentation of Darier's Disease
por: Ferizi, Mybera, et al.
Publicado: (2013)

Tight junctions in Hailey-Hailey and Darier's diseases
por: Raiko, Laura, et al.
Publicado: (2009)

Darier-White disease in siblings responding to isotretinoin
por: Bhat, Ramesh M., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_80p3rsu9oc1gfb8km8c380idll