Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia

In clinic, oral leukoplakia (OLK) may develop into oral cancer. However, the mechanism underlying this transformation is still unclear. In this work, we present a new pipeline to identify oral cancer related genes and microRNAs (miRNAs) by integrating both gene and miRNA expression profiles. In part...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Guanghui, He, Yuan, Yang, Shaofang, Chen, Beimin, Zhou, Min, Xu, Xin-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433644/
https://www.ncbi.nlm.nih.gov/pubmed/26064958
http://dx.doi.org/10.1155/2015/841956
_version_ 1782371646238097408
author Zhu, Guanghui
He, Yuan
Yang, Shaofang
Chen, Beimin
Zhou, Min
Xu, Xin-Jian
author_facet Zhu, Guanghui
He, Yuan
Yang, Shaofang
Chen, Beimin
Zhou, Min
Xu, Xin-Jian
author_sort Zhu, Guanghui
collection PubMed
description In clinic, oral leukoplakia (OLK) may develop into oral cancer. However, the mechanism underlying this transformation is still unclear. In this work, we present a new pipeline to identify oral cancer related genes and microRNAs (miRNAs) by integrating both gene and miRNA expression profiles. In particular, we find some network modules as well as their miRNA regulators that play important roles in the development of OLK to oral cancer. Among these network modules, 91.67% of genes and 37.5% of miRNAs have been previously reported to be related to oral cancer in literature. The promising results demonstrate the effectiveness and efficiency of our proposed approach.
format Online
Article
Text
id pubmed-4433644
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-44336442015-06-10 Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia Zhu, Guanghui He, Yuan Yang, Shaofang Chen, Beimin Zhou, Min Xu, Xin-Jian Biomed Res Int Research Article In clinic, oral leukoplakia (OLK) may develop into oral cancer. However, the mechanism underlying this transformation is still unclear. In this work, we present a new pipeline to identify oral cancer related genes and microRNAs (miRNAs) by integrating both gene and miRNA expression profiles. In particular, we find some network modules as well as their miRNA regulators that play important roles in the development of OLK to oral cancer. Among these network modules, 91.67% of genes and 37.5% of miRNAs have been previously reported to be related to oral cancer in literature. The promising results demonstrate the effectiveness and efficiency of our proposed approach. Hindawi Publishing Corporation 2015 2015-05-03 /pmc/articles/PMC4433644/ /pubmed/26064958 http://dx.doi.org/10.1155/2015/841956 Text en Copyright © 2015 Guanghui Zhu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhu, Guanghui
He, Yuan
Yang, Shaofang
Chen, Beimin
Zhou, Min
Xu, Xin-Jian
Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia
title Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia
title_full Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia
title_fullStr Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia
title_full_unstemmed Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia
title_short Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia
title_sort identification of gene and microrna signatures for oral cancer developed from oral leukoplakia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433644/
https://www.ncbi.nlm.nih.gov/pubmed/26064958
http://dx.doi.org/10.1155/2015/841956
work_keys_str_mv AT zhuguanghui identificationofgeneandmicrornasignaturesfororalcancerdevelopedfromoralleukoplakia
AT heyuan identificationofgeneandmicrornasignaturesfororalcancerdevelopedfromoralleukoplakia
AT yangshaofang identificationofgeneandmicrornasignaturesfororalcancerdevelopedfromoralleukoplakia
AT chenbeimin identificationofgeneandmicrornasignaturesfororalcancerdevelopedfromoralleukoplakia
AT zhoumin identificationofgeneandmicrornasignaturesfororalcancerdevelopedfromoralleukoplakia
AT xuxinjian identificationofgeneandmicrornasignaturesfororalcancerdevelopedfromoralleukoplakia

Ejemplares similares