Cargando…
Nonalcoholic Steatohepatitis: A Search for Factual Animal Models
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, which occurs in the absence of alcohol abuse. NAFLD can evolve into progressive liver injury and fibrosis in the form of nonalcoholic steatohepatitis (NASH). Several animal models have been developed to attempt to repres...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433658/ https://www.ncbi.nlm.nih.gov/pubmed/26064924 http://dx.doi.org/10.1155/2015/574832 |
_version_ | 1782371649725661184 |
---|---|
author | Sanches, Sheila Cristina L. Ramalho, Leandra Naira Z. Augusto, Marlei Josiele da Silva, Deisy Mara Ramalho, Fernando Silva |
author_facet | Sanches, Sheila Cristina L. Ramalho, Leandra Naira Z. Augusto, Marlei Josiele da Silva, Deisy Mara Ramalho, Fernando Silva |
author_sort | Sanches, Sheila Cristina L. |
collection | PubMed |
description | Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, which occurs in the absence of alcohol abuse. NAFLD can evolve into progressive liver injury and fibrosis in the form of nonalcoholic steatohepatitis (NASH). Several animal models have been developed to attempt to represent the morphological, biochemical, and clinical features of human NASH. The actual review presents a critical analysis of the most commonly used experimental models of NAFLD/NASH development. These models can be classified into genetic, nutritional, and a combination of genetic and nutritional factors. The main genetic models are ob/ob and db/db mutant mice and Zucker rats. The principal nutritional models employ methionine- and choline-deficient, high-fat, high-cholesterol and high-cholate, cafeteria, and high-fructose diets. Currently, associations between high-fructose and various compositions of high-fat diets have been widely studied. Previous studies have encountered significant difficulties in developing animal models capable of reproducing human NASH. Some models produce consistent morphological findings, but the induction method differs significantly compared with the pathophysiology of human NASH. Other models precisely represent the clinical and etiological contexts of this disease but fail to provide accurate histopathological representations mainly in the progression from steatosis to liver fibrosis. |
format | Online Article Text |
id | pubmed-4433658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44336582015-06-10 Nonalcoholic Steatohepatitis: A Search for Factual Animal Models Sanches, Sheila Cristina L. Ramalho, Leandra Naira Z. Augusto, Marlei Josiele da Silva, Deisy Mara Ramalho, Fernando Silva Biomed Res Int Review Article Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, which occurs in the absence of alcohol abuse. NAFLD can evolve into progressive liver injury and fibrosis in the form of nonalcoholic steatohepatitis (NASH). Several animal models have been developed to attempt to represent the morphological, biochemical, and clinical features of human NASH. The actual review presents a critical analysis of the most commonly used experimental models of NAFLD/NASH development. These models can be classified into genetic, nutritional, and a combination of genetic and nutritional factors. The main genetic models are ob/ob and db/db mutant mice and Zucker rats. The principal nutritional models employ methionine- and choline-deficient, high-fat, high-cholesterol and high-cholate, cafeteria, and high-fructose diets. Currently, associations between high-fructose and various compositions of high-fat diets have been widely studied. Previous studies have encountered significant difficulties in developing animal models capable of reproducing human NASH. Some models produce consistent morphological findings, but the induction method differs significantly compared with the pathophysiology of human NASH. Other models precisely represent the clinical and etiological contexts of this disease but fail to provide accurate histopathological representations mainly in the progression from steatosis to liver fibrosis. Hindawi Publishing Corporation 2015 2015-05-03 /pmc/articles/PMC4433658/ /pubmed/26064924 http://dx.doi.org/10.1155/2015/574832 Text en Copyright © 2015 Sheila Cristina L. Sanches et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sanches, Sheila Cristina L. Ramalho, Leandra Naira Z. Augusto, Marlei Josiele da Silva, Deisy Mara Ramalho, Fernando Silva Nonalcoholic Steatohepatitis: A Search for Factual Animal Models |
title | Nonalcoholic Steatohepatitis: A Search for Factual Animal Models |
title_full | Nonalcoholic Steatohepatitis: A Search for Factual Animal Models |
title_fullStr | Nonalcoholic Steatohepatitis: A Search for Factual Animal Models |
title_full_unstemmed | Nonalcoholic Steatohepatitis: A Search for Factual Animal Models |
title_short | Nonalcoholic Steatohepatitis: A Search for Factual Animal Models |
title_sort | nonalcoholic steatohepatitis: a search for factual animal models |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433658/ https://www.ncbi.nlm.nih.gov/pubmed/26064924 http://dx.doi.org/10.1155/2015/574832 |
work_keys_str_mv | AT sanchessheilacristinal nonalcoholicsteatohepatitisasearchforfactualanimalmodels AT ramalholeandranairaz nonalcoholicsteatohepatitisasearchforfactualanimalmodels AT augustomarleijosiele nonalcoholicsteatohepatitisasearchforfactualanimalmodels AT dasilvadeisymara nonalcoholicsteatohepatitisasearchforfactualanimalmodels AT ramalhofernandosilva nonalcoholicsteatohepatitisasearchforfactualanimalmodels |