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A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction
Because the clinical condition of gastrointestinal dysfunction, including functional dyspepsia, involves tangled combinations of pathologies, there are some cases of insufficient curative efficacy. Thus, traditional herbal medicines (Kampo medicines) uniquely developed in Japan are thought to contri...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433667/ https://www.ncbi.nlm.nih.gov/pubmed/26064162 http://dx.doi.org/10.1155/2015/364260 |
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author | Saegusa, Yayoi Hattori, Tomohisa Nahata, Miwa Yamada, Chihiro Takeda, Hiroshi |
author_facet | Saegusa, Yayoi Hattori, Tomohisa Nahata, Miwa Yamada, Chihiro Takeda, Hiroshi |
author_sort | Saegusa, Yayoi |
collection | PubMed |
description | Because the clinical condition of gastrointestinal dysfunction, including functional dyspepsia, involves tangled combinations of pathologies, there are some cases of insufficient curative efficacy. Thus, traditional herbal medicines (Kampo medicines) uniquely developed in Japan are thought to contribute to medical treatment for upper gastrointestinal symptoms. Rikkunshito is a Kampo medicine often used to treat dyspeptic symptoms. Over the past few years, several studies have investigated the efficacy of rikkunshito for dysmotility, for example, upper abdominal complaints, in animals and humans. Rikkunshito ameliorated the decrease in gastric motility and anorexia in cisplatin-treated rats, stress-loaded mice, and selective serotonin reuptake inhibitor-treated rats by enhancing plasma ghrelin levels via serotonin(2B/2C) receptor antagonism. In addition, rikkunshito ameliorated the decrease in food intake in aged mice and stress-loaded decreased gastric motility via enhanced ghrelin receptor signaling. Several clinical studies revealed that rikkunshito was effective in ameliorating upper gastrointestinal symptoms, including dyspepsia, epigastric pain, and postprandial fullness. In this review, we discuss these studies and propose additional evidence-based research that may promote the clinical use of Kampo medicines, particularly rikkunshito, for treating anorexia and gastrointestinal dysfunction. |
format | Online Article Text |
id | pubmed-4433667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44336672015-06-10 A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction Saegusa, Yayoi Hattori, Tomohisa Nahata, Miwa Yamada, Chihiro Takeda, Hiroshi Evid Based Complement Alternat Med Review Article Because the clinical condition of gastrointestinal dysfunction, including functional dyspepsia, involves tangled combinations of pathologies, there are some cases of insufficient curative efficacy. Thus, traditional herbal medicines (Kampo medicines) uniquely developed in Japan are thought to contribute to medical treatment for upper gastrointestinal symptoms. Rikkunshito is a Kampo medicine often used to treat dyspeptic symptoms. Over the past few years, several studies have investigated the efficacy of rikkunshito for dysmotility, for example, upper abdominal complaints, in animals and humans. Rikkunshito ameliorated the decrease in gastric motility and anorexia in cisplatin-treated rats, stress-loaded mice, and selective serotonin reuptake inhibitor-treated rats by enhancing plasma ghrelin levels via serotonin(2B/2C) receptor antagonism. In addition, rikkunshito ameliorated the decrease in food intake in aged mice and stress-loaded decreased gastric motility via enhanced ghrelin receptor signaling. Several clinical studies revealed that rikkunshito was effective in ameliorating upper gastrointestinal symptoms, including dyspepsia, epigastric pain, and postprandial fullness. In this review, we discuss these studies and propose additional evidence-based research that may promote the clinical use of Kampo medicines, particularly rikkunshito, for treating anorexia and gastrointestinal dysfunction. Hindawi Publishing Corporation 2015 2015-05-03 /pmc/articles/PMC4433667/ /pubmed/26064162 http://dx.doi.org/10.1155/2015/364260 Text en Copyright © 2015 Yayoi Saegusa et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Saegusa, Yayoi Hattori, Tomohisa Nahata, Miwa Yamada, Chihiro Takeda, Hiroshi A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction |
title | A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction |
title_full | A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction |
title_fullStr | A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction |
title_full_unstemmed | A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction |
title_short | A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction |
title_sort | new strategy using rikkunshito to treat anorexia and gastrointestinal dysfunction |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433667/ https://www.ncbi.nlm.nih.gov/pubmed/26064162 http://dx.doi.org/10.1155/2015/364260 |
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