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The Effects of Acupuncture at Real or Sham Acupoints on the Intrinsic Brain Activity in Mild Cognitive Impairment Patients

Accumulating neuroimaging studies in humans have shown that acupuncture can modulate a widely distributed brain network in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. Acupuncture at different acupoints could exert different modulatory effects on the brain network. How...

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Autores principales: Jia, Baohui, Liu, Zhishun, Min, Baoquan, Wang, Zhenchang, Zhou, Aihong, Li, Yong, Qiao, Haifa, Jia, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433670/
https://www.ncbi.nlm.nih.gov/pubmed/26064166
http://dx.doi.org/10.1155/2015/529675
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author Jia, Baohui
Liu, Zhishun
Min, Baoquan
Wang, Zhenchang
Zhou, Aihong
Li, Yong
Qiao, Haifa
Jia, Jianping
author_facet Jia, Baohui
Liu, Zhishun
Min, Baoquan
Wang, Zhenchang
Zhou, Aihong
Li, Yong
Qiao, Haifa
Jia, Jianping
author_sort Jia, Baohui
collection PubMed
description Accumulating neuroimaging studies in humans have shown that acupuncture can modulate a widely distributed brain network in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. Acupuncture at different acupoints could exert different modulatory effects on the brain network. However, whether acupuncture at real or sham acupoints can produce different effects on the brain network in MCI or AD patients remains unclear. Using resting-state fMRI, we reported that acupuncture at Taixi (KI3) induced amplitude of low-frequency fluctuation (ALFF) change of different brain regions in MCI patients from those shown in the healthy controls. In MCI patients, acupuncture at KI3 increased or decreased ALFF in the different regions from those activated by acupuncture in the healthy controls. Acupuncture at the sham acupoint in MCI patients activated the different brain regions from those in healthy controls. Therefore, we concluded that acupuncture displays more significant effect on neuronal activities of the above brain regions in MCI patients than that in healthy controls. Acupuncture at KI3 exhibits different effects on the neuronal activities of the brain regions from acupuncture at sham acupoint, although the difference is only shown at several regions due to the close distance between the above points.
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spelling pubmed-44336702015-06-10 The Effects of Acupuncture at Real or Sham Acupoints on the Intrinsic Brain Activity in Mild Cognitive Impairment Patients Jia, Baohui Liu, Zhishun Min, Baoquan Wang, Zhenchang Zhou, Aihong Li, Yong Qiao, Haifa Jia, Jianping Evid Based Complement Alternat Med Research Article Accumulating neuroimaging studies in humans have shown that acupuncture can modulate a widely distributed brain network in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. Acupuncture at different acupoints could exert different modulatory effects on the brain network. However, whether acupuncture at real or sham acupoints can produce different effects on the brain network in MCI or AD patients remains unclear. Using resting-state fMRI, we reported that acupuncture at Taixi (KI3) induced amplitude of low-frequency fluctuation (ALFF) change of different brain regions in MCI patients from those shown in the healthy controls. In MCI patients, acupuncture at KI3 increased or decreased ALFF in the different regions from those activated by acupuncture in the healthy controls. Acupuncture at the sham acupoint in MCI patients activated the different brain regions from those in healthy controls. Therefore, we concluded that acupuncture displays more significant effect on neuronal activities of the above brain regions in MCI patients than that in healthy controls. Acupuncture at KI3 exhibits different effects on the neuronal activities of the brain regions from acupuncture at sham acupoint, although the difference is only shown at several regions due to the close distance between the above points. Hindawi Publishing Corporation 2015 2015-05-03 /pmc/articles/PMC4433670/ /pubmed/26064166 http://dx.doi.org/10.1155/2015/529675 Text en Copyright © 2015 Baohui Jia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jia, Baohui
Liu, Zhishun
Min, Baoquan
Wang, Zhenchang
Zhou, Aihong
Li, Yong
Qiao, Haifa
Jia, Jianping
The Effects of Acupuncture at Real or Sham Acupoints on the Intrinsic Brain Activity in Mild Cognitive Impairment Patients
title The Effects of Acupuncture at Real or Sham Acupoints on the Intrinsic Brain Activity in Mild Cognitive Impairment Patients
title_full The Effects of Acupuncture at Real or Sham Acupoints on the Intrinsic Brain Activity in Mild Cognitive Impairment Patients
title_fullStr The Effects of Acupuncture at Real or Sham Acupoints on the Intrinsic Brain Activity in Mild Cognitive Impairment Patients
title_full_unstemmed The Effects of Acupuncture at Real or Sham Acupoints on the Intrinsic Brain Activity in Mild Cognitive Impairment Patients
title_short The Effects of Acupuncture at Real or Sham Acupoints on the Intrinsic Brain Activity in Mild Cognitive Impairment Patients
title_sort effects of acupuncture at real or sham acupoints on the intrinsic brain activity in mild cognitive impairment patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433670/
https://www.ncbi.nlm.nih.gov/pubmed/26064166
http://dx.doi.org/10.1155/2015/529675
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