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The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors

Bone metastases are frequent and debilitating consequence for many tumors, such as breast, lung, prostate, and kidney cancer. Many studies report the importance of the immune system in the pathogenesis of bone metastasis. Indeed, bone and immune system are strictly linked to each other because bone...

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Detalles Bibliográficos
Autores principales: D'Amico, Lucia, Roato, Ilaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433688/
https://www.ncbi.nlm.nih.gov/pubmed/26064994
http://dx.doi.org/10.1155/2015/143526
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author D'Amico, Lucia
Roato, Ilaria
author_facet D'Amico, Lucia
Roato, Ilaria
author_sort D'Amico, Lucia
collection PubMed
description Bone metastases are frequent and debilitating consequence for many tumors, such as breast, lung, prostate, and kidney cancer. Many studies report the importance of the immune system in the pathogenesis of bone metastasis. Indeed, bone and immune system are strictly linked to each other because bone regulates the hematopoietic stem cells from which all cells of the immune system derive, and many immunoregulatory cytokines influence the fate of bone cells. Furthermore, both cytokines and factors produced by immune and bone cells promote the growth of tumor cells in bone, contributing to supporting the vicious cycle of bone metastasis. This review summarizes the current knowledge on the interactions among bone, immune, and tumor cells aiming to provide an overview of the osteoimmunology field in bone metastasis from solid tumors.
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spelling pubmed-44336882015-06-10 The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors D'Amico, Lucia Roato, Ilaria J Immunol Res Review Article Bone metastases are frequent and debilitating consequence for many tumors, such as breast, lung, prostate, and kidney cancer. Many studies report the importance of the immune system in the pathogenesis of bone metastasis. Indeed, bone and immune system are strictly linked to each other because bone regulates the hematopoietic stem cells from which all cells of the immune system derive, and many immunoregulatory cytokines influence the fate of bone cells. Furthermore, both cytokines and factors produced by immune and bone cells promote the growth of tumor cells in bone, contributing to supporting the vicious cycle of bone metastasis. This review summarizes the current knowledge on the interactions among bone, immune, and tumor cells aiming to provide an overview of the osteoimmunology field in bone metastasis from solid tumors. Hindawi Publishing Corporation 2015 2015-05-03 /pmc/articles/PMC4433688/ /pubmed/26064994 http://dx.doi.org/10.1155/2015/143526 Text en Copyright © 2015 L. D'Amico and I. Roato. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
D'Amico, Lucia
Roato, Ilaria
The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors
title The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors
title_full The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors
title_fullStr The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors
title_full_unstemmed The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors
title_short The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors
title_sort impact of immune system in regulating bone metastasis formation by osteotropic tumors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433688/
https://www.ncbi.nlm.nih.gov/pubmed/26064994
http://dx.doi.org/10.1155/2015/143526
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