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The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors
Bone metastases are frequent and debilitating consequence for many tumors, such as breast, lung, prostate, and kidney cancer. Many studies report the importance of the immune system in the pathogenesis of bone metastasis. Indeed, bone and immune system are strictly linked to each other because bone...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433688/ https://www.ncbi.nlm.nih.gov/pubmed/26064994 http://dx.doi.org/10.1155/2015/143526 |
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author | D'Amico, Lucia Roato, Ilaria |
author_facet | D'Amico, Lucia Roato, Ilaria |
author_sort | D'Amico, Lucia |
collection | PubMed |
description | Bone metastases are frequent and debilitating consequence for many tumors, such as breast, lung, prostate, and kidney cancer. Many studies report the importance of the immune system in the pathogenesis of bone metastasis. Indeed, bone and immune system are strictly linked to each other because bone regulates the hematopoietic stem cells from which all cells of the immune system derive, and many immunoregulatory cytokines influence the fate of bone cells. Furthermore, both cytokines and factors produced by immune and bone cells promote the growth of tumor cells in bone, contributing to supporting the vicious cycle of bone metastasis. This review summarizes the current knowledge on the interactions among bone, immune, and tumor cells aiming to provide an overview of the osteoimmunology field in bone metastasis from solid tumors. |
format | Online Article Text |
id | pubmed-4433688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44336882015-06-10 The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors D'Amico, Lucia Roato, Ilaria J Immunol Res Review Article Bone metastases are frequent and debilitating consequence for many tumors, such as breast, lung, prostate, and kidney cancer. Many studies report the importance of the immune system in the pathogenesis of bone metastasis. Indeed, bone and immune system are strictly linked to each other because bone regulates the hematopoietic stem cells from which all cells of the immune system derive, and many immunoregulatory cytokines influence the fate of bone cells. Furthermore, both cytokines and factors produced by immune and bone cells promote the growth of tumor cells in bone, contributing to supporting the vicious cycle of bone metastasis. This review summarizes the current knowledge on the interactions among bone, immune, and tumor cells aiming to provide an overview of the osteoimmunology field in bone metastasis from solid tumors. Hindawi Publishing Corporation 2015 2015-05-03 /pmc/articles/PMC4433688/ /pubmed/26064994 http://dx.doi.org/10.1155/2015/143526 Text en Copyright © 2015 L. D'Amico and I. Roato. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article D'Amico, Lucia Roato, Ilaria The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors |
title | The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors |
title_full | The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors |
title_fullStr | The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors |
title_full_unstemmed | The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors |
title_short | The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors |
title_sort | impact of immune system in regulating bone metastasis formation by osteotropic tumors |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433688/ https://www.ncbi.nlm.nih.gov/pubmed/26064994 http://dx.doi.org/10.1155/2015/143526 |
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