Pharmacological investigations of new galantamine peptide esters

Galantamine hydrobromide (GAL) is a reversible acetylcholinesterase inhibitor, with properties to increase the concentration of acetylcholine in several brain structures. The aim of this study is to determine the effect of new galantamine peptide esters: 3,4-dichlorophenyl-alanil-leucil-glycine-gala...

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Autores principales: Tsvetkova, Dobrina, Danchev, Nikolai, Nikolova, Irina, Obreshkova, Danka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Articles; Pharmaceutical Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433837/
https://www.ncbi.nlm.nih.gov/pubmed/26019502
http://dx.doi.org/10.1080/13102818.2014.901685
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author Tsvetkova, Dobrina
Danchev, Nikolai
Nikolova, Irina
Obreshkova, Danka
author_facet Tsvetkova, Dobrina
Danchev, Nikolai
Nikolova, Irina
Obreshkova, Danka
author_sort Tsvetkova, Dobrina
collection PubMed
description Galantamine hydrobromide (GAL) is a reversible acetylcholinesterase inhibitor, with properties to increase the concentration of acetylcholine in several brain structures. The aim of this study is to determine the effect of new galantamine peptide esters: 3,4-dichlorophenyl-alanil-leucil-glycine-galantamine (GAL-LEU) and 3,4-dichlorophenyl-alanil-valil-glycine-galantamine (GAL-VAL), on locomotor activity in mice and cognitive processes in experimental model of learning and memory in rats. The results showed that per oral administration of GAL-LEU in a dose of 3 mg per kg improved the cognitive processes by increasing the conditional avoidances and learning ability after the 5th day of application and preserved the memory at the 12th day of the study.
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spelling pubmed-44338372015-05-25 Pharmacological investigations of new galantamine peptide esters Tsvetkova, Dobrina Danchev, Nikolai Nikolova, Irina Obreshkova, Danka Biotechnol Biotechnol Equip Articles; Pharmaceutical Biotechnology Galantamine hydrobromide (GAL) is a reversible acetylcholinesterase inhibitor, with properties to increase the concentration of acetylcholine in several brain structures. The aim of this study is to determine the effect of new galantamine peptide esters: 3,4-dichlorophenyl-alanil-leucil-glycine-galantamine (GAL-LEU) and 3,4-dichlorophenyl-alanil-valil-glycine-galantamine (GAL-VAL), on locomotor activity in mice and cognitive processes in experimental model of learning and memory in rats. The results showed that per oral administration of GAL-LEU in a dose of 3 mg per kg improved the cognitive processes by increasing the conditional avoidances and learning ability after the 5th day of application and preserved the memory at the 12th day of the study. Taylor & Francis 2014-01-02 2014-06-04 /pmc/articles/PMC4433837/ /pubmed/26019502 http://dx.doi.org/10.1080/13102818.2014.901685 Text en © 2014 The Author(s). Published by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Articles; Pharmaceutical Biotechnology
Tsvetkova, Dobrina
Danchev, Nikolai
Nikolova, Irina
Obreshkova, Danka
Pharmacological investigations of new galantamine peptide esters
title Pharmacological investigations of new galantamine peptide esters
title_full Pharmacological investigations of new galantamine peptide esters
title_fullStr Pharmacological investigations of new galantamine peptide esters
title_full_unstemmed Pharmacological investigations of new galantamine peptide esters
title_short Pharmacological investigations of new galantamine peptide esters
title_sort pharmacological investigations of new galantamine peptide esters
topic Articles; Pharmaceutical Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433837/
https://www.ncbi.nlm.nih.gov/pubmed/26019502
http://dx.doi.org/10.1080/13102818.2014.901685
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AT obreshkovadanka pharmacologicalinvestigationsofnewgalantaminepeptideesters

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