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VEGF expression, microvessel density and dendritic cell decrease in thyroid cancer

Thyroid cancer is one of the five most common cancers in the age between 20 and 50 years. Many factors including the potent angiogenic vascular endothelial growth factor (VEGF) and different dendritic cell types are known to be related to thyroid tumourogenesis. The study was performed to address th...

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Autores principales: Gulubova, Maya, Ivanova, Koni, Ananiev, Julian, Gerenova, Julieta, Zdraveski, Aleksandar, Stoyanov, Hristo, Vlaykova, Tatyana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433839/
https://www.ncbi.nlm.nih.gov/pubmed/26019537
http://dx.doi.org/10.1080/13102818.2014.909151
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author Gulubova, Maya
Ivanova, Koni
Ananiev, Julian
Gerenova, Julieta
Zdraveski, Aleksandar
Stoyanov, Hristo
Vlaykova, Tatyana
author_facet Gulubova, Maya
Ivanova, Koni
Ananiev, Julian
Gerenova, Julieta
Zdraveski, Aleksandar
Stoyanov, Hristo
Vlaykova, Tatyana
author_sort Gulubova, Maya
collection PubMed
description Thyroid cancer is one of the five most common cancers in the age between 20 and 50 years. Many factors including the potent angiogenic vascular endothelial growth factor (VEGF) and different dendritic cell types are known to be related to thyroid tumourogenesis. The study was performed to address the expression of VEGF and microvessel density in thyroid cancers and to evaluate the effect of VEGF expression in thyroid tumour cells on the dendritic cells. We investigated 65 patients with different types of thyroid carcinomas: papillary (PTC), oncocytic (OTC), follicular (FTC) and anaplastic (ATC), immunohistochemically with antibodies against VEGF, CD1a, CD83, S100 and CD31. Our results suggest that the expression of VEGF is significantly more often in PTC than ATC (92.3% vs. 60.0%, p = 0.025). The microvessel density marked with CD31 in the tumour border of PTC was significantly higher as compared to FTC (p = 0.039), but not to ATC and OTC (p = 0.337 and 0.134). We found that CD1a- and CD83-positive cells were dispersed with variable density and in OC CD31(+) vessel numbers were positively correlated with CD83(+) dendritic cells in tumour stroma (R = 0.847, p = 0.016). We did not find statistically significant associations of the survival of patients with PTC after the surgical therapy with VEGF expression and MVD. In conclusion we may state that VEGF expression in tumour cells of thyroid cancer can induce neovascularization and suppress dendritic cells.
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spelling pubmed-44338392015-05-25 VEGF expression, microvessel density and dendritic cell decrease in thyroid cancer Gulubova, Maya Ivanova, Koni Ananiev, Julian Gerenova, Julieta Zdraveski, Aleksandar Stoyanov, Hristo Vlaykova, Tatyana Biotechnol Biotechnol Equip Articles; Medical Biotechnology Thyroid cancer is one of the five most common cancers in the age between 20 and 50 years. Many factors including the potent angiogenic vascular endothelial growth factor (VEGF) and different dendritic cell types are known to be related to thyroid tumourogenesis. The study was performed to address the expression of VEGF and microvessel density in thyroid cancers and to evaluate the effect of VEGF expression in thyroid tumour cells on the dendritic cells. We investigated 65 patients with different types of thyroid carcinomas: papillary (PTC), oncocytic (OTC), follicular (FTC) and anaplastic (ATC), immunohistochemically with antibodies against VEGF, CD1a, CD83, S100 and CD31. Our results suggest that the expression of VEGF is significantly more often in PTC than ATC (92.3% vs. 60.0%, p = 0.025). The microvessel density marked with CD31 in the tumour border of PTC was significantly higher as compared to FTC (p = 0.039), but not to ATC and OTC (p = 0.337 and 0.134). We found that CD1a- and CD83-positive cells were dispersed with variable density and in OC CD31(+) vessel numbers were positively correlated with CD83(+) dendritic cells in tumour stroma (R = 0.847, p = 0.016). We did not find statistically significant associations of the survival of patients with PTC after the surgical therapy with VEGF expression and MVD. In conclusion we may state that VEGF expression in tumour cells of thyroid cancer can induce neovascularization and suppress dendritic cells. Taylor & Francis 2014-05-04 2014-09-25 /pmc/articles/PMC4433839/ /pubmed/26019537 http://dx.doi.org/10.1080/13102818.2014.909151 Text en © 2014 The Author(s). Published by Taylor & Francis. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Articles; Medical Biotechnology
Gulubova, Maya
Ivanova, Koni
Ananiev, Julian
Gerenova, Julieta
Zdraveski, Aleksandar
Stoyanov, Hristo
Vlaykova, Tatyana
VEGF expression, microvessel density and dendritic cell decrease in thyroid cancer
title VEGF expression, microvessel density and dendritic cell decrease in thyroid cancer
title_full VEGF expression, microvessel density and dendritic cell decrease in thyroid cancer
title_fullStr VEGF expression, microvessel density and dendritic cell decrease in thyroid cancer
title_full_unstemmed VEGF expression, microvessel density and dendritic cell decrease in thyroid cancer
title_short VEGF expression, microvessel density and dendritic cell decrease in thyroid cancer
title_sort vegf expression, microvessel density and dendritic cell decrease in thyroid cancer
topic Articles; Medical Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433839/
https://www.ncbi.nlm.nih.gov/pubmed/26019537
http://dx.doi.org/10.1080/13102818.2014.909151
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